Chemical Biology
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Chemical BiologyCoordinator Other lecturers Objectives methodological areas that has spurred many of the recent forward leaps of Biology, both in the ability to interrogate it and to manipulate its function. At the end of this CU students should have recognized and assimilated the new possibilities that emerge when biological problems are tackled by the articulate use of knowledge arising from different areas like synthetic and natural product chemistry, pharmacology, biochemistry and structural biochemistry. In this context, teaching is centered on some of the essential tools of Chemical Biology (CB) and its objective is to form a way of thinking and researching Biology, which is crucial to consolidate at the entry of a PhD program. From the vast area of real and conceptual aspects of CB this CU will focus on topics judged to have higher immediate impact and broader formative profile. Syllabus 1. Molecular recognition and binding Analyzing molecular recognition and binding; 2. Drug design, discovery and resistance Optimization of lead-target interactions 3. Self-assembling bio-inspired systems Supramolecular interactions involved in peptide/protein self-assembly Protein in vitro evolution for recognition or function (Catalysis) Minimal and artificial versions of enzymes. Functional assays. 4. Chemical methods to synthesize DNA, RNA for diagnostics and therapeutics. Synthesis of oligonucleotides and incorporation of non-natural nucleotides; siRNA and rybozymes. 5. Chemical methods to synthesize proteins and peptides Incorporation of non-natural amino acids. Design and Applications of “de novo” proteins 6. Bioconjugates and for in vivo and. Protein-drug conjugates Biocompatible click reactions and bioorthogonal reactions. 7. Labelling Strategies for Cell Biology 8. Artificial Nanoparticles, their synthesis and functionalisation Evaluation Main Bibliography
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