[AVX Seminar] New Tissue Engineering Strategies for the Regeneration of Several Tissues
Rui L Reis, 3B's Research Group, University of Minho, Guimarães, Portugal
| When |
02 Oct, 2014
from
11:00 am to 12:00 pm |
|---|---|
| Where | Auditorium |
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AVX Seminar
Title: New Tissue Engineering Strategies for the Regeneration of Several Tissues
Speaker: Rui L Reis
Affiliation: Director of the 3B's Research Group - Biomaterials, Biodegradables and Biomimetics, University of Minho, Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine, Taipas – Guimarães, Portugal | President of the ICVS/3B´s - PT Government Associated Laboratory, Braga/Guimarães, Portugal | Editor-in-Chief of the Journal of Tissue Engineering and Regenerative Medicine (TERM), John Wiley & Sons - Blackwell, CEO of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine
Abstract:
The selection of a scaffold material is both a critical and difficult choice that will determine the success of failure of any tissue engineering (TE) strategy. We believe that natural origin polymers are the best choice for many approaches. In addition, we have been developing an all range of processing methodologies to produce adequate scaffolds for different TE applications. Furthermore an adequate cell source should be selected. In many cases efficient cell isolation, expansion and differentiation methodologies should be developed and optimized. We have been using different human cell sources namely: mesenchymal stem cells from bone marrow, mesenchymal stem cells from human adipose tissue, human cells from amniotic fluids and membranes and cells obtained from human umbilical cords. The potential of each type of cells, to be used to develop novel useful regeneration therapies will be discussed. Their uses and their interactions with different natural origin degradable scaffolds and distinct nano and micro-carriers, and smart release systems, will be described. A great focus will be given to the different sources of stem cells, the isolation of distinct sub-populations, ways of differentiating them, as well as their interactions with different 3D architectures and materials for culturing them. The use of bioreactors to control cell differentiation, as well as the surface modification of the materials in order to control cell adhesion and proliferation will also be illustrated. Several biomimetic and nanotechnology based strategies to engineer mineralized tissues will be described.
