[Course] CERMAX practical course on Basic NMR

Short course

The "CERMAX practical course on Basic NMR" is an initiation course to the Nuclear Magnetic Resonance technique with a solid basic theoretical component and a strong practical and theoretical-practical component. The course has a duration of one week starting on a Monday afternoon and ending on the following Friday afternoon with a practical component of 9 hours of use of 500 MHz spectrometers and 13 hours of theoretical and theoretical-practical classes.

The curricular structure includes the following topics: Introduction to NMR spectroscopy-The phenomenon and signal characteristics/information; Instrumental aspects of the spectrometer/Rules for spectrometer use; Sample preparation; 1D Acquisition and processing; Introduction to 2D NMR spectroscopy (Homonuclear correlation); The Nuclear Overhauser Effect; Heteronuclear correlation for small molecule; Protein assignment and structure; The paramagnetic effect and metalloproteins; Residual Dipolar Couplings and disordered proteins; NMR and Metabolomics; Quantitative NMR; and Assignment strategies in small molecules.
 

Credits: 1.5 ECTS
 

Target audience

The course is available to all those who need/want basic training in the area of Magnetic Resonance, but is especially aimed at master's or doctoral students in the life sciences and analytical technicians in the areas of Pharmaceutical Chemistry, Health and Veterinary Sciences. The trainees must have a university degree in the areas of Chemistry and Biology.
 

Number of participants

6-12
 

Applications

From 12 AUG to 06 SEP 

Registration fee: 25€

Enrollment: 15€

Tuition: 750€*

* - Fellowships are available for eligible students, under the PRR regulations (see Official Notice).
 

Course dates

From 07 to 11 OCT 2024

Evaluation: 18 OCT

Location: ITQB NOVA 
 

Official Announcement
 

Faculty

Luís Gafeira

Helena Matias

Pedro Lamosa

Ricardo Louro

Tiago Cordeiro
 

Program

7 OCT

14.00 – Introduction to NMR spectroscopy.            

15.30 – Break

15.50 – Instrumental aspects of the spectrometer / Rules for spectrometer use              

16.30 – Spectrometer Guided tour and sample preparation                                                       

8 OCT

9.30 – 1D Acquisition and processing                                                              

10.15 – Introduction to 2D NMR spectroscopy (Homonuclear correlation)        

11.00 – Break

11.30 – The Nuclear Overhauser Effect                                                            

12.30 – Lunch break

14.00 – Heteronuclear correlation for small molecule                                   

15.00 – Protein assignment and structure                                                                          

9 OCT

9.30 – The paramagnetic effect and metalloproteins                                        

10.15 – Residual Dipolar Couplings and disordered proteins                       

11.00 – Break

11.15 – Practical session I - Acquisition (1D, presat, p90, APT) | Processing and analyzing 1D

13.30 – Lunch break

14.30 – Practical sessions I (cont)                                                                                                          

10 OCT

9.30 – NMR and Metabolomics/ Quantitative NMR    

11.00 – Break

11.15 – Practical session II - Acquisition (COSY, HSQC) | Processing and analyzing 2D

13.30 – Lunch break

14.30 – Practical sessions II (cont)                                                                                         

11 OCT

9.30 – Assignment strategies in small molecules (tutorial and exercises)        

10.45 – Break

11.15 – Assignment strategies (cont)                                                               

13.00 – Lunch break

14.00 – Practical session III - Aquisition exercises

Sponsors

Tecnimede

This course is supported by European funds under the Recovery and Resilience Plan (PRR) of the Portuguese Republic, following the approval of the "CIVIC and GLOBAL" project of Universidade NOVA de Lisboa (RE - C06.i03.03 - Impulso Adultos), through fellowhips for elegible students under the PRR regulations.

The Recovery and Resilience Plan is a nationally applicable programme. The Plan will implement a set of reforms and investments aimed at restoring sustained economic growth, supporting the goal of convergence with Europe over the next decade.

The European Union, faced with the serious impacts of the pandemic on European economies, has created Next Generation EU, a strategic instrument to mitigate the economic and social impact of the crisis; this is capable of promoting economic convergence and resilience, helping to ensure long-term sustainable growth and meeting the challenges of the transition to a greener and more digital society. The Recovery and Resilience Mechanism has been developed on the basis of this instrument, and the RRP fits into this framework.

The RRP is an investment plan for all Portuguese people, based on three structuring dimensions: Resilience; Climate Change; Digital Transition.

More information.