SCAN:Localization of proteins involved in bacterial cell wall synthesis and cell division

Abstract:

Bacteria carefully regulate their shape by coordinating cell division and growth of the cell wall. Growth and division requires the action, at the right time and at the right place, of various proteins which are thought to be organised in large complexes. Key questions in both processes are how proteins within these complexes interact, how proteins localize to their site of action and whether the proposed ‘multiprotein-complexes’ consisting of cytosolic, inner membrane and periplasmic proteins in fact exist.
During the SCAN I will present examples of earlier work on localization and protein-protein interactions of cell division and cell wall synthesis proteins. Subsequently I will outline the work that will be undertaken in the Bacterial Membrane Proteomics laboratory, aimed at identifying and characterizing the ‘multiprotein-complexes’ involved in bacterial growth and division.