Studies on the resolution of 4-hydroxycycloalkenones derivatives
PhD Seminar: Paula Rodrigues, Organic Synthesis Lab
| When |
11 Nov, 2009
from
12:20 pm to 12:40 pm |
|---|---|
| Where | Auditorium |
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PhD Seminars
Title: Studies on the resolution of 4-hydroxycycloalkenones derivatives via stereoselective formation of 2-oxoazabicyclo-[x.1.0]-alkanes.
Speaker: Paula Rodrigues
Laboratory: Organic Synthesis
Abstract:
The importance of 4-hydroxycloalkenones as structural units in many biologically active compounds, have attracted the attention of chemists and has resulted in the development of various methods for obtaining them in enantiomerically pure form.
One of our studies in this area has been directed towards the synthesis of intermediates of such kind of compounds in optically active form via the direct resolution of 4-tert-butyldimethylsiloxy-2-iodo-cycloalkenones using an aziridination protocol.
The aziridination also constitutes a good method for the protection of the enone system and a useful stereodirecting strategy. In addition, several natural products contain these strained three-membered rings within their structures
Short CV
Since January 2007- PhD fellowship under supervision of Professor Christopher Maycock.
January 2005- Master’s degree in Bioenergy by the Faculdade de Ciência e Tecnologia of Universidade Nova de Lisboa.
December 1999- Degree in Chemistry by the Universidade do Minho, Braga.
