Complexes of macrocyclic ligands with arms containing phosphorus atoms for medicinal chemistry
Přemysl Lubal, Masaryk University, Czech Republic
| When |
20 Jul, 2009
from
02:00 pm to 04:00 pm |
|---|---|
| Where | Room 2.13 |
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Seminar
Title: Complexes of macrocyclic ligands with arms containing phosphorus atoms for medicinal chemistry
Speaker: Přemysl Lubal
Affiliation: Department of Analytical Chemistry, Faculty of Science, Masaryk University, Brno, Czech Republic
Host: Rita Delgado - "Coordination and Supramolecular Chemistry" Lab.
Short Abstract:
Complexes of macrocyclic ligands having pendant arms containing acetate/phosphorus acids and its derivatives are utilized in many areas of medicine (e.g. complexes of metal radioisotopes as 64/67Cu, 90Y, 153Sm, 166Ho, 177Lu in nuclear medicine in radiodiagnostics and radiotherapy; Gd(III), Fe(III) or Mn(II) complexes as MRI contrast agents, Eu(III) or Tb(III) complexes as luminescent probes). They are used as bifunctional chelating agents (BFC) that contain macrocyclic ligand as metal coordination unit attached to biologically active molecules responsible for the distribution in body. The complexes should exhibit high thermodynamic stability and, of course, kinetic inertness under physiological conditions. Therefore, it is necessary to know thermodynamic and kinetic properties (dissociation rate constants) of complexes in order to find the best macrocyclic BFC for possible medical application in vivo. The lecture will discuss the structural design of macrocyclic ligands for BFC synthesis from both thermodynamic/kinetic point.
