Frontier Leaders: The Chemistry of Oxygen Sensing in Humans (TIME CHANGE)

Frontier Leaders of Today
for the Scientists of Tomorrow

ITQB PhD Program Seminar Series

Title: The Chemistry of Oxygen Sensing in Humans

Speaker: Christopher Schofield

Affiliation: University of Oxford, UK

Abstract:

The lecture will give an introduction to the chemistry and physiology of oxygen sensing and its importance in animal biology followed by description of the discovery of the oxygen sensing enzymes and characterisation of their properties. The implications of these finding for pharmaceutical work and basic science will be described along with recent work on post-translational modifications and their role in regulating gene expression / epigenetics will be discussed. Although the work described addresses at biological and medicinal problems, the lecture will be very much be from a chemical perspective.

Professor Christopher Schofield, University of Oxford

Main scientific interests:

Oxygenases; Mechanisms of the hypoxic response; Oxygen regulation of gene expression; Mechanism of action and development of new antibiotics

Short Biography:

1982  Degree in Chemistry, University of Manchester
1985   D.Phil, University of Oxford
1985 - 1990 Postdoctoral Research, Organic Chemistry Dept., University of Oxford
1990 – 1998 Lecturer in Organic Chemistry, University of Oxford
1998 –             Professor of Chemistry and Fellow of Hertford College, University of Oxford

Publications
Author of over 400 papers (including Nature, Science and Cell), with over 5,000 citations and h-index of 41

Seminar Series Poster