Pathological modeling, drug discovery and toxicity testing using pluripotent stem cells
Marc Peschanski Scientific Director-(I-STEM, INSERM/UEVE)
| When |
02 Mar, 2011
from
03:00 pm to 04:00 pm |
|---|---|
| Where | Auditorium |
| Add event to your calendar |
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ITQB – IBET SEMINAR
Title: Pathological modeling, drug discovery and toxicity testing using pluripotent stem cells
Speaker: Marc Peschanski MD PhD
Affiliation: Scientific Director, Institute for Stem Cell Therapy and Exploration of Monogenic Diseases (I-STEM, INSERM/UEVE)-(Evry, France)
Biography
Marc Peschanski MD PhD, I-STEM director
Hired as a Research Associate at INSERM in 1982, he had obtained previously a MD and a PhD from the University of Paris, the latter on the neurophysiology of pain. He did a post-doctoral training at UC San Francisco. He built his first own team on pain relay neurons in the thalamus, that he analyzed using physiological and anatomical approaches.
From 1985 on, he has changed topics and undertaken in parallel basic research dealing with brain neuroplasticity and pre-clinical studies aiming at using those newly described capacity of adult neurons for therapeutic purposes with fetal neural grafts. In 1991, he moved to the Hospital Henri-Mondor in Créteil to start a translational research INSERM unit that carried out clinical trials of fetal neural grafts (then gene therapy) in patients with Parkinson’s and Huntington’s disease. Positive results of the latter clinical trial in a disease which has no other known treatment, has led to the organisation of a multi-centre European-wide phase II trial.
Since 2005, he has started a new venture by creating the first and largest Institute for stem cell research in France, I-STEM, dedicated to the exploration of therapeutic potentials of stem cells for therapeutics in rare diseases of genetic origin. I-STEM currently comprises more than 75 people in 10 research teams interested in neurological diseases, myopathies, cardiomyopathies, retinitis and genodermatoses. He has been one of the founders of NECTAR, the Network for European CNS Transplantation And Restoration, and its first chairman (1991-92). He has founded the Clinical Investigation Centre in Créteil in 2001 and coordinated its activity up to 2006.
