[Seminar] Regulation of receptor kinase-mediated immune signaling

Plants for Life 2017 - Invited Speakers

Title: Regulation of receptor kinase-mediated immune signaling

Speaker: Cyril Zipfel

Affiliation: The Sainsbury Laboratory, Norwich Research Park, Norwich, UK

Host: Nelson Saibo

Abstract:

Cell surface receptor kinases are essential to perceive extracellular stimuli and to modulate cellular outputs during growth and development, as well as in response to environmental challenges. In plants, several pattern recognition receptors (PRRs) involved in ‘non-self’ innate immune perception are receptor kinases, often found in heteromeric kinase complexes. Appropriate immune signaling initiation, timing and amplitude must be carefully regulated to avoid excessive or unspecific activation of immune responses, which can lead to autoimmune and inflammatory diseases. The mechanisms and pathways that negatively regulate innate immunity in mammals have been extensively characterised. However, much less is known in plants, where a fine balance between immunity and growth is important for their optimal fitness. I will present recent work illustrating how PRR-mediated innate immune signaling is tightly regulated