[SCAN Highlight] Molecular structure of FoxE, the putative iron oxidase of Rhodobacter ferrooxidans SW2
Carlos Frazão, Structural Biology Lab, ITQB NOVA
| When |
18 Oct, 2017
from
12:00 pm to 01:00 pm |
|---|---|
| Where | Auditorium |
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SCAN Paper Highlight
Title: Molecular structure of FoxE, the putative iron oxidase of Rhodobacter ferrooxidans SW2,
Speaker: Carlos Frazão
Affiliation: Structural Biology Lab, ITQB NOVA
Article:
L. Pereira, I.H. Saraiva, A.S. F. Oliveira, C.M. Soares, R.O. Louroa,C. Frazão, ITQB NOVA
BBA - Bioenergetics 1858 (2017) 847–853, http://dx.doi.org/10.1016/j.bbabio.2017.07.002
Abstract:
The ancient metabolism of photoferrotrophy likely played a key role in the biogeochemical cycle of iron on Early Earth, leading to deposition of Banded Iron Formations prior to the emergence of oxygenic photosynthesis. Rhodobacter ferrooxidans SW still performs this metabolism, providing a convenient window to peer into those molecular mechanisms. The structure analysis of its terminal iron oxidase, FoxE, allowed to understand how iron oxidation can be performed in the periplasmic space of this Gram-negative bacterium at circumneutral pH, while minimizing the risk of mineral precipitation and cell encrustation.
