[SCAN] Manipulation of mammalian host cells by Salmonella

SCAN

Title: Manipulation of mammalian host cells by Salmonella

Speaker: Jaime Mota

Affiliation: UCIBIO-REQUINTE, Life Sciences Dept., FCT NOVA

Abstract:

Salmonella enterica are facultative intracellular bacteria that cause gastroenteritis, typhoid fever, and non-typhoidal bacteraemia in humans. Salmonella virulence is related to its capacity to multiply within host cells in a membrane-bound compartment, the Salmonella-containing vacuole, and depends on type III secretion systems that are used to deliver bacterial effector proteins into host cells. In this seminar, I will present an overview of mechanisms involved in Salmonella virulence that are related to its type III secretion systems and summarize our studies on the cellular function of the Salmonella effector protein SteA. I will present and discuss data indicating that: (i) SteA contributes to control the complex interaction between the bacterial vacuole and host cell vesicular trafficking pathways, possibly by interfering with host microtubule molecular motors; (ii) the precise localization of SteA within host cells depends on its interaction with the host cell phospholipid phosphatidylinositol 4-phosphate, which reveals that subcellular targeting of Salmonella effectors involves mechanisms that are common to eukaryotic proteins.