SCAN:Therapy with CO: where are we?
Carlos C. Romão Head of Organometallic Chemistry Laboratory
| When |
11 May, 2011
from
12:00 pm to 01:00 pm |
|---|---|
| Where | Auditorium |
| Add event to your calendar |
iCal
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ITQB- SCAN Seminar
Title: Therapy with CO: where are we?
Speaker: Carlos C. Romão
From: Head of Organometallic Chemistry Laboratory
Abstract:
The therapeutic potential of carbon monoxide (CO) has been realized about one decade ago. Its pleiotropic signaling role provides a very large number of opportunities for therapy given its anti-inflammatory, anti-apoptotic and cytoprotective properties, namely in the endothelial healing.
In spite of some highly significant positive therapeutic results in animal models of multiple sclerosis, cerebral malaria, sickle cell disease to cite only those that were developed in this Associate Laboratory, CO gas has severe limitations to be administered as a drug.
In order to circumvent this problem CO-releasing molecules (CO-RM) were proposed by three independent laboratories in 2001-2002. The laboratory of Organometallic Chemistry at ITQB, harbored the seed for the appearance of Alfama which has led this line of discovery since 2005.
The progress made in these years in the quest of a CO based drug as well as the challenges ahead and the dire straits of the present will be reviewed and discussed.
