[Seminar] Chiral spiro catalysts and their applications in asymmetric hydrogenation of ketones

Title: Chiral spiro catalysts and their applications in asymmetric hydrogenation of ketones

Speaker: Qi-Lin Zhou

From: College of Chemistry, Nankai University, Tianjin, China

Abstract: Chiral catalyst is the key for the catalytic asymmetric synthesis. In last few decades many chiral catalysts have been developed. However, most of the reported chiral catalysts showed high activity and enantioselectivity for limited reactions, sometime for only limited substrates. Very few chiral catalysts provided satisfying activity and enantioselectivity for a wide range of mechanistically unrelated reactions. Recently, we developed a new type of chiral catalysts which have a spirobiindane framework. Chiral spiro catalysts exhibited excellent activity and enantioselectivity for wide range of reactions, such as asymmetric hydrogenation, carbon-carbon bond and carbon-heteroatom bond-forming reactions. This lecture will present the design and synthesis of chiral spiro catalysts and their applications in asymmetric hydrogenation of various ketones.

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