[Seminar] Engineering Biomolecular Affinity
Roberto Lins, Instituto Aggeu Magalhães, Brazil
| When |
22 Jun, 2017
from
11:00 am to 12:00 pm |
|---|---|
| Where | Room 2.13 |
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Seminar
Title: Engineering Biomolecular Affinity
Speaker: Roberto Lins
Affiliation: Instituto Aggeu Magalhães, Oswaldo Cruz Foundation, Brazil
Host: Prof. Cláudio M. Soares, Protein Modeling
Abstract:
Protein engineering is directed towards finding or tunning properties of a specific system. However, conformational instability of the engineered chimeras often leads to loss of native conformation followed by degradation and/or aggregation, therefore limiting success rate. To overcome this issue, we have devised a protocol that combines de novo and molecular dynamics techniques to address biomolecular affinity in a predictive manner. The talk will showcase examples in how to design antigen-antibody interactions, enzyme catalysis and protein adhesion to cardiac devices and mineral surface.
