[Seminar] Physicochemical principles of phase separation in cell physiology and disease
Avinash Patel, Max Planck Institute of Molecular Cell Biology and Genetics, Germany
| When |
19 Dec, 2018
from
02:30 pm to 03:30 pm |
|---|---|
| Where | Room 2.13 |
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Seminar
Title: Physicochemical principles of phase separation in cell physiology and disease
Speaker: Avinash Patel
Affiliation: Max Planck Institute of Molecular Cell Biology and Genetics, Germany
Abstract:
The discovery of phase separation in cytoplasm has provided a novel set of physicochemical principles to describe compartmentalisation in cells. I will address how phase separation not only creates crucibles to isolate and influence reactions but also leads to an enhanced risk of driving aggregation of disease causing proteins.
References:
Patel et al. ATP as a biological hydrotrope. Science. 2017 May 19;356(6339):753-756. http://science.sciencemag.org/content/356/6339/753
Patel et al. A Liquid-to-Solid Phase Transition of the ALS Protein FUS Accelerated by Disease Mutation. Cell. 2015 Aug 27;162(5):1066-77. https://www.ncbi.nlm.nih.gov/pubmed/26317470
