ITQB NOVA Publications

X-ray structure of full-length human RuvB-Like 2 – mechanistic insights into coupling between ATP binding and mechanical action.
Silva STN, Brito JA, Arranz R, Sorzano CÓS, Ebel C, Doutch J, Tully MD, Carazo JM, Carrascosa JL, Matias PM, Bandeiras TM.
Sci. Rep. 2018; 8:13726.

The direct role of selenocysteine in [NiFeSe] hydrogenase maturation and catalysis.
Marques MC, Tapia C, Gutiérrez-Sanz O, Ramos AR, Keller KL, Wall JD, De Lacey AL, Matias PM, Pereira IAC.
Nat. Chem. Biol. 2017; 13: 544-550.

SAXS structural studies of Dps from Deinococcus radiodurans highlights the conformation of the mobile N-terminal extensions.
Santos SP, Cuypers MG, Round A, Finet S, Narayanan T, Mitchell EP, Romão CV.
JMB 2017; 429: 667-687.

The key role of glutamate 172 in the mechanism of type II NADH:quinone oxidoreductase of Staphylococcus aureus
Sousa FM, Sena FV, Batista AP, Athayde D, Brito JA, Archer M, Oliveira ASF, Soares CM, Catarino T, Pereira MM.
Biochim Biophys Acta. 2017; 185: 823-832

Molecular structure of FoxE, the putative iron oxidase of Rhodobacter ferrooxidans SW2.
Pereira L, Saraiva IH, Oliveira ASF, Soares CM, Louro RO, Frazão C.
BBA – Bioenergetics. 2017; 1858:847-853.

Electron Accepting Units of the Diheme Cytochrome c TsdA, a Bifunctional Thiosulfate Dehydrogenase/Tetrathionate Reductase.
Kurth JM, Brito JA, Reuter J, Flegler A, Koch T, Franke T, Klein EM, Rowe SF, Butt JN, Denkmann K, Pereira IA, Archer M, Dahl C.
J Biol Chem. 2016: 291: 24804-24818.

Clickable 4-Oxo-β-lactam-Based Selective Probing for Human Neutrophil Elastase Related Proteomes.
Ruivo EF, Gonçalves LM, Carvalho LA, Guedes RC, Hofbauer S, Brito JA, Archer M, Moreira R, Lucas SD. Chem Med Chem. 2016; 11:2037-2042.

S-Adenosyl-l-methionine Modulates CO and NO• Binding to the Human H2S-generating Enzyme Cystathionine β-Synthase.
Vicente JB, Colaço HG, Sarti P, Leandro P, Giuffrè A.
J Biol Chem. 2016; 291:572-581.

The Terminal Oxidase Cytochrome bd Promotes Sulfide-resistant Bacterial Respiration and Growth.
Forte E, Borisov VB, Falabella M, Colaço HG, Tinajero-Trejo M, Poole RK, Vicente JB, Sarti P, Giuffrè A.
Sci Rep. 2016; 6:23788.

Structural and functional characterization of two unusual endonuclease III enzymes from Deinococcus radiodurans.
Sarre A, Ökvist M, Klar T, Hall DR, Smalås AO, McSweeney S, Timmins J, Moe E.
J Struct Biol. 2015; 191: 87-99.

Thiosulfate dehydrogenase (TsdA) from Allochromatium vinosum: structural and functional insights into thiosulfate oxidation.
Brito JA, Denkmann K, Pereira IA, Archer M, Dahl C.
J Biol Chem. 2015; 290:9222-9238.

Surface enhanced vibrational spectroscopic evidence for an alternative DNA-independent redox activation of endonuclease III.
Moe E, Sezer M, Hildebrandt P, Todorovic S.
Chem Commun (Camb). 2015; 51:3255-3257.

RuvbL1 and RuvbL2 enhance aggresome formation and disaggregate amyloid fibrils.
Zaarur N, Xu X, Lestienne P, Meriin AB, McComb M, Costello CE, Newnam GP, Ganti R, Romanova NV, Shanmugasundaram M, Silva ST, Bandeiras TM, Matias PM, Lobachev KS, Lednev IK, Chernoff YO, Sherman MY.
EMBO Journal. 2015; 112: 11455-11460.

Dps from Deinococcus radiodurans: oligomeric forms of Dps1 with distinct cellular functions and Dps2 involved in metal storage.
Santos SP, Mitchell EP, Franquelim HG, Castanho MA, Abreu IA, Romão CV.
FEBS J. 2015; 282: 4307-27.

KSHV but not MHV-68 LANA induces a strong bend upon binding to terminal repeat viral DNA.
Ponnusamy R, Petoukhov MV, Correia B, Custodio TF, Juillard F, Tan M, Pires de Miranda M, Carrondo MA, Simas JP, Kaye KM, Svergun DI, McVey CE
Nucleic Acids Res. 2015; 43:10039-10054.

X-ray structure of a CDP-alcohol phosphatidyltransferase membrane enzyme and insights into its catalytic mechanism.
Nogly P, Gushchin I, Remeeva A, Esteves AM, Borges N, Ma P, Ishchenko A, Grudinin S, Round E, Moraes I, Borshchevskiy V, Santos H, Gordeliy V, Archer M.
Nat Commun. 2014; 5:4169.