Cancer research

Many anticancer drugs fail in clinical trials due to lack of efficacy. To increase the number of well succeeded drug candidates, more predictive models for pre-clinical discovery are required. Tumor cell lines adapted to proliferate in 2D culture dishes, fail however to recapitulate physiological cell-cell, cell-matrix, and other microenvironment contacts.

At the Animal Cell Technology (ACT) Unit, we are working on the development of 3D in vitro cancer models that better mimic solid tumors by conjugating bioreactor technology and multicellular aggregate approaches.