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2011

2011

  1. Vicente T, Mota JP, Peixoto C, Alves PM, Carrondo MJ, 2011. Rational design and optimization of downstream processes of virus particles for biopharmaceutical applications: current advances. Biotechnol Adv, 29: 869-78. http://dx.doi.org/10.1016/j.biotechadv.2011.07.004
  2. Vieira HL, Alves PM, Vercelli A, 2011. Modulation of neuronal stem cell differentiation by hypoxia and reactive oxygen species. Prog Neurobiol, 93:444-55. http://dx.doi.org/10.1016/j.pneurobio.2011.01.007
  3. Lamego J, Coroadinha AS, Simplicio AL, 2011. Detection and quantification of carboxylesterase 2 activity by capillary electrophoresis. Anal Chem, 83(3):881–887. http://dx.doi.org/10.1021/ac102547c
  4. Carrondo MJ, Panet A, Wirth D, Coroadinha AS, Cruz P, Falk H, Schucht R, Dupont F, Geny-Fiamma C, Merten OW, Hauser H, 2011. Integrated strategy for the production of therapeutic retroviral vectors. Hum Gene Ther, 22(3): 370-79. http://dx.doi.org/10.1089/hum.2009.165
  5. Gama-Norton L, Botezatu L, Herrmann S, Schweizer M, Alves PM, Hauser H, Wirth D, 2011. Lentivirus production is influenced by SV40 large T-antigen and chromosomal integration of the vector in HEK293 cells. Hum Gene Ther, 22(10):1269-79. http://dx.doi.org/10.1089/hum.2010.143
  6. Serra M, Correia C, Malpique R, Brito C, Jensen J, Bjorquist P, Carrondo MJ, Alves PM, 2011. Microencapsulation technology: a powerful tool for integrating expansion and cryopreservation of human embryonic stem cells. Plos One, 6(8) e23212. http://dx.doi.org/10.1371/journal.pone.0023212
  7. Carinhas N, Robitaille AM, Moes S, Carrondo MJ, Jenoe P, Oliveira R, Alves PM, 2011. Quantitative proteomics of Spodoptera frugiperda cells during growth and baculovirus infection. Plos One, 6(10):e26444. http://dx.doi.org/10.1371/journal.pone.0026444
  8. Teixeira AP, Duarte TM, Carrondo MJ, Alves PM, 2011. Synchronous fluorescence spectroscopy as a novel tool to enable PAT applications in bioprocesses. Biotechnol Bioeng, 108(8):1852-61. http://dx.doi.org/10.1002/bit.23131
  9. Tostões RM, Leite SB, Miranda JP, Sousa MF, Wang DIC, Carrondo MJ, Alves PM, 2011. Perfusion of 3D encapsulated hepatocytes-a synergistic effect enhancing long-term functionality in bioreactors. Biotechnol Bioeng, 108: 41-49. http://dx.doi.org/10.1002/bit.22920
  10. Rodrigues AF, Guerreiro MR, Santiago VM, Dalba C, Klatzmann D, Alves PM, Carrondo MJ, Coroadinha AS, 2011. Down-regulation of CD81 tetraspanin in human cells producing retroviral-based particles: tailoring vector composition. Biotechnol Bioeng, 108(11):2623-33. http://dx.doi.org/10.1002/bit.23231
  11. Vicente T, Fáber R, Alves PM, Carrondo MJ, Mota JP, 2011. Impact of ligand density on the optimization of ion-exchange membrane chromatography for viral vector purification. Biotechnol Bioeng, 108(6):1347-59. http://dx.doi.org/10.1002/bit.23058
  12. Silva AC, Carrondo MJ, and Alves PM, 2011. Strategies for improved stability of Peste des Petits Ruminants vaccine. Vaccine, 29:4983-91. http://dx.doi.org/10.1016/j.vaccine.2011.04.102
  13. Real G, Monteiro F, Burger C, Alves PM, 2011. Improvement of lentiviral transfer vectors using cis-acting regulatory elements for increased gene expression. Appl Microbiol Biotechnol, 91:1581-91. http://dx.doi.org/10.1007/s00253-011-3392-2
  14. Teixeira AP, Dias JM, Carinhas N, Sousa MF, Clemente JJ, Cunha AE, Von Stosch M, Alves PM, Carrondo MJ, Oliveira R, 2011. Cell functional enviromics: unravelling the function of environmental factors. BMC Syst Biol, 5:92. http://dx.doi.org/10.1186/1752-0509-5-92
  15. Carinhas N, Bernal V, Teixeira AP, Carrondo MJ, Alves PM, Oliveira R, 2011. Hybrid metabolic flux analysis: combining stoichiometric and statistical constraints to model the formation of complex recombinant products. BMC Syst Biol, 5:34. http://dx.doi.org/10.1186/1752-0509-5-34
  16. Lesch HP, Laitinen A, Peixoto C, Vicente T, Makkonen ME, Laitinen L, Pikkarainen JT, Samaranayake H, Alves PM, Carrondo MJ, Ylä-Herttuala S, Airenne KJ, 2011. Production and Purification of lentiviral vectors generated in 293T suspension cells with baculoviral vectors. Gene Ther, 18:531-38. http://dx.doi.org/10.1038/gt.2010.162
  17. Teixeira AP, Duarte TM, Oliveira R, Carrondo MJ, Alves PM, 2011. High-throughput analysis of animal cell cultures using two dimensional fluorometry. J Biotechnol, 151:255-60. http://dx.doi.org/10.1016/j.jbiotec.2010.11.015
  18. Santos SS, Sonnewald U, Carrondo MJ, Alves PM, 2011. The role of glia in neuronal recovery following anoxia: in vitro evidence of neuronal adaptation. Neurochem Int, 58:665-75. http://dx.doi.org/10.1016/j.neuint.2011.02.005
  19. Leite SB, Teixeira AP, Miranda JP, Tostoes RM, Clemente JJ, Sousa MF, Carrondo MJ, Alves PM, 2011. Merging bioreactor technology with 3D hepatocyte-fibroblast culturing approaches: improved in vitro models for Toxicological applications. Toxicol in Vitro, 25(4):825-32. http://dx.doi.org/10.1016/j.tiv.2011.02.002
  20. Queiroga CS, Almeida AS, Alves PM, Brenner C, Vieira HL, 2011. Carbon monoxide prevents hepatic mitochondrial membrane permeabilization. BMC Cell Biol 12:10. http://dx.doi.org/10.1186/1471-2121-12-10
  21. Amaral AI , Teixeira AP, Sonnewald U, Alves PM, 2011. Estimation of intracellular fluxes in cerebellar neurons after hypoglyce: importance of the pyruvate recycling pathway and glutamine oxidation. J Neurosci Res, 89(5)-700:10. http://dx.doi.org/10.1002/jnr.22571
  22. Vicente T, Roldão A, Peixoto C, Carrondo MJ, Alves PM, 2011. Large-scale production and purification of VLP-based vaccines. J Invertebr Pathol, 107:S42-S48. http://dx.doi.org/10.1016/j.jip.2011.05.004
  23. Carvalhal AV, Santos SS, Carrondo MJ, 2011. Extracellular purine and pyrimidine catabolism in cell culture. Biotechnol Prog, 27:1373-82. http://dx.doi.org/10.1002/btpr.656
  24. Roldão A, Vicente T, Peixoto C, Carrondo MJ, Alves PM, 2011. Quality control and analytical methods for baculovirus based products. J Invertebr Pathol, 107:S94-S105. http://dx.doi.org/10.1016/j.jip.2011.05.009
  25. Amaral IA, Teixeira AP, Håkonsen BI, Sonnewald U, Alves PM, 2011. A comprehensive metabolic profile of cultured astrocytes using isotopic transient metabolic flux analysis and 13C-labelled glucose. Front Neuroenerg, 3:5. http://dx.doi.org/10.3389/fnene.2011.00005
  26. Adler S, Basketter D, Creton S, Pelkonen O, van Benthem J, Zuang V, Andersen KE, Angers-Loustau A, Aptula A, Bal-Price A, Benfenati E, Bernauer U, Bessems J, Bois FY, Boobis A, Brandon E, Bremer S, Broschard T, Casati S, Coecke S, Corvi R, Cronin M, Daston G, Dekant W, Felter S, Grignard E, Gundert-Remy U, Heinonen T, Kimber I, Kleinjans J, Komulainen H, Kreiling R, Kreysa J, Mazzatorta P, Maxwell G, Munn S, Leite SB, Loizou G, Pfuhler S, Phrakonkham P, Piersma A, Poth A, Prieto P, Repetto G, Rogiers V, Schoeters G, Schwarz M, Serafimova R, Tähti H, Testai E, van Delft J, van Loveren H, Vinken M, Worth A, Zaldivar JM, 2011. Alternative (non-animal) methods for cosmetics testing: current status and future prospects. Arch Toxicol, 85(5):367-485. http://dx.doi.org/10.1007/s00204-011-0693-2
  27. Tavares L, Alves PM, Ferreira RB, Santos CN, 2011. Comparison of different methods for DNA-free RNA isolation from SK-N-MC neuroblastoma. BMC Res Notes, 1:140. http://dx.doi.org/10.1186/1756-0500-4-3
  28. Mandenius, C.-F., Andersson, T. B., Alves, P. M., Batzl-Hartmann, C., Björquist, P., Carrondo, M. J. T., … Zeilinger, K., 2011. Toward Preclinical Predictive Drug Testing for Metabolism and Hepatotoxicity by Using In Vitro Models Derived from Human Embryonic Stem Cells and Human Cell Lines — A Report on the Vitrocellomics EU-project. Alternatives to Laboratory Animals, 39(2), 147–171. https://doi.org/10.1177/026119291103900210

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