2014
2014
- Rodrigues AF, Carrondo MJ, Alves PM, Coroadinha AS 2014. Cellular targets for improved manufacturing of virus-based biopharmaceuticals in animal cells. Trends in Biotechnology, 32(12):602-7. http://dx.doi.org/10.1016/j.tibtech.2014.09.010
- Nestola P, Martins DL, Peixoto C, Roederstein S, Schleuss T, Alves PM, Mota JPB, Carrondo MJ. 2014. Evaluation of Novel Large Cut-Off Ultrafiltration Membranes for Adenovirus Serotype 5 (Ad5) Concentration. PLoS ONE, 9(12):-115802. http://dx.doi.org/10.1371/journal.pone.0115802
- Nestola P, Silva RJS, Peixoto C, Alves PM, Carrondo MJT, Mota JPB. 2014. Adenovirus purification by two-column, size-exclusion, simulated countercurrent chromatography. Journal of Chromatography A,1347: 111–121. http://dx.doi.org/10.1016/j.chroma.2014.04.079
- Nestola P, Villain L, Peixoto C, Martins DL, Alves PM, Carrondo MJT, Mota JPB. 2014. Impact of grafting on the design of new membrane adsorbers for adenovirus purification. Journal of Biotechnology, 181: 1–11. http://dx.doi.org/10.1016/j.jbiotec.2014.04.003
- Duarte TM, Carinhas N, Barreiro LC, Carrondo MJT, Alves PM, Teixeira AP. 2014. Metabolic responses of CHO cells to limitation of key amino acids. Biotechnol Bioeng, 111(10): 2095-2106. http://dx.doi.org/10.1002/bit.25266
- Silva AC, Yami M, Libeau G, Carrondo MJ, Alves PM. 2014. Testing a new formulation for Peste des Petits Ruminants vaccine in Ethiopia. Vaccine, 32(24): 2878–81. http://dx.doi.org/10.1016/j.vaccine.2014.02.039
- Patrone M, Carinhas N, Sousa MQ, Peixoto C, Ciferri C, Carfì A, Alves PM. 2014. Enhanced expression of full-length human cytomegalovirus fusion protein in non-swelling baculovirus-infected cells with a minimal fed-batch strategy. PloS One. 9(3): e90753. http://dx.doi.org/10.1371/journal.pone.0090753
- Fernandes F, Dias MM, Vidigal J, Sousa MF, Patrone M, Teixeira AP, Alves PM. 2014. Production of rotavirus core-like particles in Sf9 cells using recombinase-mediated cassette exchange. J Biotechnol. 171(10): 34–8. http://dx.doi.org/10.1016/j.jbiotec.2013.11.020
- Monteiro F, Bernal V, Saelens X, Lozano AB, Bernal C , Sevilla A, Carrondo MJT, Alves PM. 2014. Metabolic profiling of insect cell lines: Unveiling cell line determinants behind system’s Productivity. Biotechnol Bioeng. 111(4): 816–28. http://dx.doi.org/10.1002/bit.25142
- Pais DAM, Carrondo MJT, Alves PM, Teixeira AP. 2014. Towards real-time monitoring of therapeutic protein quality in mammalian cell processes. Current Opinion in Biotechnology. Jul 15;30C:161-167. http://dx.doi.org/10.1016/j.copbio.2014.06.019.
- Correia C, Serra M, Espinha N, Sousa M, Brito C, Burkert K, Zheng Y, Hescheler J, Carrondo MJ, Sarić T, Alves PM. 2014. Combining Hypoxia and Bioreactor Hydrodynamics Boosts Induced Pluripotent Stem Cell Differentiation Towards Cardiomyocytes. Stem Cell Reviews and Reports. Published on line 15 July 2014. http://dx.doi.org/10.1007/s12015-014-9533-0
- Gualda EJ, Simão D, Pinto C, Alves PM, Brito C. 2014. Imaging of human differentiated 3D neural aggregates using light sheet fluorescence. Frontiers in Cellular Neuroscience, 8:221. http://dx.doi.org/10.3389/fncel.2014.00221
- Hickman J, Graeser R, De Hoogt R, Vidic S, Brito C, Gutekunst M, Van der Kuip H. 2014. Capturing tumor complexity in vitro/ex vivo: three dimensional models of cancer for pharmacology and cancer cell biology. Biotechnology Journal. Biotechnology Journal, 9: 1115-28. http://dx.doi.org/10.1002/biot.201300492
- Bessems JG, Loizou G, Krishnan K, Clewell HJ 3rd, Bernasconi C, Bois F, Coecke S, Collnot EM, Diembeck W, Farcal LR, Geraets L, Gundert-Remy U, Kramer N, Küsters G, Leite SB, Pelkonen OR, Schröder K, Testai E, Wilk-Zasadna I, Zaldívar-Comenges JM. 2014. PBTK modelling platforms and parameter estimation tools to enable animal-free risk assessment: recommendations from a joint EPAA--EURL ECVAM ADME workshop. Regul Toxicol Pharmacol. Feb;68(1):119-39. https://doi.org/10.1016/j.yrtph.2013.11.008