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2021

  1. Almeida HV, Tenreiro MF, Louro AF, Abecasis B, Santinha D, Calmeiro T, Fortunato E, Ferreira L, Alves PM, Serra M. Human Extracellular-Matrix Functionalization of 3D hiPSC-Based Cardiac Tissues Improves Cardiomyocyte Maturation. ACS Applied Bio Materials. 2021. 4(2): 1888. doi:10.1021/acsabm.0c01490
  2. Lopes N, Correia VG, Palma AS, Brito C. Cracking the Breast Cancer Glyco-Code through Glycan-Lectin Interactions: Targeting Immunosuppressive Macrophages. International Journal of Molecular Sciences. 2021. 22(4): 1972. doi:10.3390/ijms22041972
  3. Castro R, Nobre LS, Eleutério RP, Thomaz M, Pires A, Monteiro SM, Mendes S, Gomes RA, Clemente JJ, Sousa MFQ, Pinto F, Silva AC, Freitas MC, Lemos AR, Akpogheneta O, Kosack L, Bergman ML, Duarte N, Matoso P, Costa J, Bandeiras TM, Gomes-Alves P, Gonçalves CP, Demengeot J, Alves PM. Production of high-quality SARS-CoV-2 antigens: Impact of bioprocess and storage on glycosylation, biophysical attributes, and ELISA serologic tests performance. Biotechnology and Bioengineering. 2021. 118(6). doi:10.1002/bit.27725 
  4. Domenici G, Eduardo R, Castillo-Ecija H, Orive G, Carcaboso AM, Brito C. PDX-Derived Ewing’s Sarcoma Cells Retain High Viability and Disease Phenotype in Alginate Encapsulated Spheroid Cultures. Cancers. 2021. 13(4): 879. doi:10.3390/cancers13040879
  5. Isidro IA, Vicente P, Pais DAM, Almeida JI, Domingues M, Abecasis B, Zapata-Linares N, Rodriguez-Madoz JR, Prosper F, Aspegren A, Alves PM, Serra M. Online monitoring of hiPSC expansion and hepatic differentiation in 3D culture by dielectric spectroscopy. Biotechnology & Bioengineering. 2021. doi:10.1002/bit.27751
  6. Sampaio-Pinto V, Janssen J, Chirico N, Serra M, Alves PM, Doevendans PA, Voets IK, Sluijter JPG, van Laake LW, van Mil A. A Roadmap to Cardiac Tissue-engineered Construct Preservation: Insights From Cells, Tissues and Organs. Advanced Materials. 2021. doi:10.1002/adma.202008517
  7. Batalha S, Ferreira S, Brito C. The Peripheral Immune Landscape of Breast Cancer: Clinical Findings and In Vitro Models for Biomarker Discovery. Cancers. 2021. 13(6): 1305. doi:10.3390/cancers13061305
  8. Sebastião MJ, Marcos-Silva L, Gomes-Alves P, Alves PM. Proteomic and Glyco(proteo)mic tools in the profiling of cardiac progenitors and pluripotent stem cell derived cardiomyocytes: Accelerating translation into therapy. Biotechnology Advances. 2021. doi:10.1016/j.biotechadv.2021.107755
  9. Arez F, Rodrigues AF, Brito C, Alves PM. Bioengineered Liver Cell Models of Hepatotropic Infections. Viruses. 2021. 13(5): 773. doi:10.3390/v13050773
  10. Carvalho SB, Peixoto C, Carrondo MJT, Silva R. Downstream processing for influenza vaccines and candidates: an update. Biotechnology and Bioengineering. 2021. doi: 10.1002/bit.27803
  11. Franchi-Mendes T, Lopes N, Brito C. Heterotypic tumor spheroids in agitation-based cultures: a scaffold-free cell model that sustains long-term survival of endothelial cells. Frontiers in Bioengineering and Biotechnology. 2021. doi: 10.3389/fbioe.2021.649949
  12. Correia R, Meneses L, Richheimer C, Alves PM, Carrondo MJT, Duarte ARC, Paiva A, Roldão A. Improved storage of influenza HA-VLPs using a trehalose-glycerol natural deep eutectic solvent system. Vaccine. 2021. doi:10.1016/j.vaccine.2021.04.033
  13. Fernandes B, Correia R, Sousa M, Carrondo MJT, Roldão A. Integrating high cell density cultures with adapted laboratory evolution for improved Gag-HA virus-like particles production in stable insect cell lines. Biotechnology and Bioengineering. 2021. doi: 10.1002/bit.27766
  14. Dias MM, Vidigal J, Sequeira DP, Alves PM, Teixeira AP, Roldão A. Insect High FiveTM cell line development using site-specific flipase recombination technology. G3 Genes|Genomes|Genetics. 2021. doi: 10.1093/g3journal/jkab166
  15. Tenreiro MF, Louro AF, Alves PM, Serra M. Next generation of heart regenerative therapies: progress and promise of cardiac tissue engineering. npj regenerative medicine. 2021. 6:30 (2021). doi: 10.1038/s41536-021-00140-4
  16. Sales-Dias J, Ferreira A, Lamy M, Domenici G, Monteiro SMS, Pires A, Lemos AR, Kucheryava K, Nobre LS, Sousa PMF, Bandeiras TM, Silva G, Barbas A. Development of antibodies against the notch ligand Delta-Like-1 by phage display with activity against breast cancer cells. New Biotechnology. 2021. 64: 17-26. doi: 10.1016/j.nbt.2021.05.003
  17. Sebastião MJ, Serra M, Gomes-Alves P, Alves PM. Stem cells characterization: OMICS reinforcing analytics. Current Opinion in Biotechnology. 2021. 20;71:175-181. doi: 10.1016/j.copbio.2021.07.021
  18. Silva G, Sales-Dias J, Casal D, Alves S, Domenici G, Barreto C, Matos C, Lemos AR, Matias AT, Kucheryava K, Ferreira A, Moita MR, Braga S, Brito C, Cabral MG, Casalou C, Barral DC, Sousa PMF, Videira PA, Bandeiras TM, Barbas A. Development of Dl1.72, a Novel Anti-DLL1 Antibody with Anti-Tumor Efficacy against Estrogen Receptor-Positive Breast Cancer. MDPI Cancers 2021. 13(16), 4074. doi: 10.3390/cancers13164074
  19. Cox MC, Mendes R, Silva F, Mendes TF, Zelaya-Lazo A, Halwachs K, Purkal JJ, Isidro IA, Félix A, Boghaert ER, Brito C. Application of LDH assay for therapeutic efficacy evaluation of ex vivo tumor models. Scientific Reports. 2021. 11: 18571. doi: 10.1038/s41598-021-97894-0
  20. Franchi‐Mendes T, Eduardo R, Domenici G, Brito C. 3D Cancer Models: Depicting Cellular Crosstalk within the Tumour Microenvironment. MDPI Cancers. 2021. 13: 4610. doi: 10.3390/cancers13184610
  21. Mata S, Franchi-Mendes T, Abreu S, Filipe B, Morgado S, Mesquita M, Albuquerque C, Fonseca R, Santo VE, Boghaert ER, Rosa I, Brito C. Patient-Derived Explants of Colorectal Cancer: Histopathological and Molecular Analysis of Long-Term Cultures. MDPI Cancers. 2021. 13 (18): 4695. doi: 10.3390/cancers13184695
  22. Pimentel-Santos FM, Rodrigues Manica S, Masi Alfonse T, Lagoas-Gomes J, Santos MB, Ramiro S, Sepriano A, Nair K, Costa J, Gomes-Alves P, Branco JC. Lumbar myofascial physical properties in healthy adults: myotonometry vs. shear wave elastography measurements. Acta Reumatol Port. 2021. 46:110-119.
  23. Tenreiro MF, Almeida HV, Calmeiro T, Fortunato E, Ferreira L, Alves PM, Serra M. Interindividual heterogeneity affects the outcome of human cardiac tissue decellularization. Scientific Reports. 2021. 11: 20834. doi:10.1038/s41598-021-00226-5
  24. Moreira AS, Faria TQ, Oliveira JG, Kavara A, Schofield M, Sanderson T, Collins M, Gantier R, Alves PM, Carrondo MJT, Peixoto C. Enhancing the purification of Lentiviral vectors for clinical applications. Separation and Purification Technology. 2021. 274: 118598. doi:10.1016/j.seppur.2021.118598 
  25. Mendes JP, Silva RJS, Berg M, Mathiasson L, Peixoto C, Alves PM, Carrondo MJT. Oncolytic virus purification with periodic counter-current chromatography. Biotechnology and Bioengineering. 2021. 118:3522–3532. doi:10.1002/bit.27779
  26. Almeida JI, Tenreiro MF, Martinez-Santamaria L, Aspizua SG, Gisbert JP, Alves PM, Serra M, Baptista PM. Hallmarks of the human intestinal microbiome on liver maturation and function. 2021. doi:10.1016/j.jhep.2021.10.015
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