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Previous years

2006

  1. Coroadinha AS, Silva AC, Pires E, Coelho A, Alves PM, Carrondo MJ, 2006. Effect of osmotic pressure on the production of retroviral vectors: enhancement in vector stability. Biotechnol Bioeng, 94(2):322-9. http://dx.doi.org/10.1002/bit.20847
  2. Coroadinha AS, Ribeiro J, Roldão A, Cruz PE, Alves PM, Merten O-W, Carrondo MJ, 2006. Effect of medium sugar source on the production of retroviral vectors for gene therapy. Biotechnol Bioeng, 94(1):24-36. http://dx.doi.org/10.1002/bit.20778
  3. Marcelino I, Sousa MF, Veríssimo C, Cunha A, Carrondo MJ, Alves PM, 2006. Process development for the mass production of Ehrlichia ruminantium. Vaccine, 24(10):1716-25. http://dx.doi.org/10.1016/j.vaccine.2005.08.109
  4. Coroadinha AS, Alves PM, Santos SS, Cruz PE, Merten, OW, Carrondo MJ, 2006. Retrovirus producer cell line metabolism: implications on viral productivity. Appl Microbiol Biotechnol. 72(6):1125-35. http://dx.doi.org/10.1007/s00253-006-0401-y
  5. Antonis AF, Bruschke CJ, Rueda P, Maranga L, Casal JI, Vela C, Hilgers LA, Belt PB, Weerdmeester K, Carrondo MJ, Langeveld JP, 2006. A novel recombinant virus-like particle vaccine for prevention of porcine parvovirus-induced reproductive failure. Vaccine, 24(26):5481-90. http://dx.doi.org/10.1016/j.vaccine.2006.03.089
  6. Schucht R, Coroadinha AS, Zanta-Boussif MA, Verhoeyen E, Carrondo MJ, Hauser H, Wirth D, 2006. A new generation of retroviral producer cells: predictable and stable virus production by Flp-mediated site-specific integration of retroviral vectors. Mol Ther, 14(2):285-92. http://dx.doi.org/10.1016/j.ymthe.2005.12.003
  7. Coroadinha AS, Schucht R, Gama-Norton L, Wirth D, Hauser H, Carrondo MJ, 2006. The use of recombinase mediated cassette exchange in retroviral vector producer cell lines: predictability and efficiency by transgene exchange. J Biotechnol, 124(2):457-68. http://dx.doi.org/10.1016/j.jbiotec.2006.01.037
  8. Lameiro MH, Malpique R, Silva AC, Alves PM, Melo E, 2006. Encapsulation of adenoviral vectors into chitosan-bile salt microparticles for mucosal vaccination, J Biotechnol, 126:152-62. http://dx.doi.org/10.1016/j.jbiotec.2006.04.030
  9. Lameiro MH, Lopes A, Martins LO, Alves PM, Melo E, 2006. Incorporation of a model protein into chitosan-bile salt microparticles. Int J Pharm, 312:119-30. http://dx.doi.org/10.1016/j.ijpharm.2006.01.006
  10. Brennan L, Alves PM, Hewage C, Malthouse JG, McBean GJ, 2006. Impact of gliotoxin L-serine-O-suphate on cellular metabolism in cultured astrocytes. Neurochem Int, 48:739-45. http://dx.doi.org/10.1016/j.neuint.2005.12.004
  11. Carmo M, Faria TQ, Falk H, Coroadinha AS, Teixeira M, Merten OW, Geny-Fiamma C, Alves PM, Danos O, Panet A, Carrondo MJ, Cruz PE, 2006. Relationship between retroviral vector membrane and vector stability. J Gen Virol, 87(5):1349-56. http://dx.doi.org/10.1099/vir.0.81302-0
  12. Cruz PE, Silva AC, Roldao A, Carmo M, Carrondo MJ, Alves PM, 2006. Screening of novel excipients for improving the stability of retroviral and adenoviral vectors. Biotechnol Prog, 22(2):568-76. http://dx.doi.org/10.1021/bp050294y
  13. Teixeira AP, Clemente JJ, Cunha AE, Carrondo MJ, Oliveira R, 2006. Bioprocess iterative batch-to-batch optimization based on hybrid parametric/nonparametric models. Biotechnol Prog, 22(1):247-58. http://dx.doi.org/10.1021/bp0502328
  14. Peixoto C, Ferreira TB, Carrondo MJ, Cruz PE, Alves PM, 2006. Purification of adenoviral vectors using expanded bed chromatography. J Virol Methods, 132:121-6. http://dx.doi.org/10.1016/j.jviromet.2005.10.002
  15. Rodrigues T, Carvalho A, Roldao A, Carrondo MJ, Alves PM, Cruz PE, 2006. Screening anion-exchange chromatographic matrices for isolation of onco-retroviral vectors. J Chromatogr B, 837(1-2):59-68. http://dx.doi.org/10.1016/j.jchromb.2006.03.061
  16. Roldão A, Vieira HL, Alves PM, Oliveira R, Carrondo MJ, 2006. Intracellular dynamics in rotavirus-like particles production: evaluation of multigene and monocistronic infection strategies. Proc Biochem, 41:2188-99. http://doi:10.1016/j.procbio.2006.06.019
  17. Santos SS, Gibson GE, Cooper AJ, Denton TT, Thompson CM, Bunik VI, Alves PM, Sonnewald U, 2006. Inhibitors of the a-ketoglutarate dehydrogenase complex alter [1-13C]Glucose and [U-13C]Glutamate metabolism in cerebellar granule neurons. J Neurosci Res, 83:450-8. http://dx.doi.org/10.1002/jnr.20749
  18. Vieira HL, Pereira AC, Carrondo MJ, Alves PM, 2006. Catalase effect on apoptosis for the improvement of recombinant protein production in baculovirus-insect cell system. Bioprocess Biosyst Eng, 29(5-6):409-14. http://dx.doi.org/10.1007/s00449-006-0093-9
  19. Zhang C, Ferreira TB, Cruz PE, Alves PM, Haury M, Carrondo MJ, 2006. The importance of 293 cell cycle phase on adenovirus vector production. Enzyme Microb Technol, 39:1328-32. http://dx.doi.org/10.1016/j.enzmictec.2006.03.021

2005

  1. Marcelino I, Veríssimo C, Sousa MF, Carrondo MJ, Alves PM, 2005. Characterization of Ehrlichia ruminantium replication and release kinetics in endothelial cell cultures. Vet Microbiol, 110:87-96. http://dx.doi.org/10.1016/j.vetmic.2005.07.012
  2. Peixoto CC, Marcelino I, Vachiéry N, Bensaid A, Martinez D, Carrondo MJ, Alves PM, 2005. Quantification of Ehrlichia ruminantium by real time PCR. Vet Microbiol, 107:273-8. http://dx.doi.org/10.1016/j.vetmic.2005.02.001
  3. Ferreira TB, Ferreira AL, Carrondo MJ, Alves PM, 2005. Effect of refeed strategies and non-ammoniagenic medium on adenovirus production at high cell densities. J Biotechnol, 119:272-80. http://dx.doi.org/10.1016/j.jbiotec.2005.03.009
  4. Vieira HL, Estevão C, Roldão A, Peixoto CC, Sousa MF, Cruz PE, Carrondo MJ, Alves PM, 2005. Triple layered rotavirus VLP assembly: kinetics of vector replication, mRNA stability and recombinant protein production. J Biotechnol, 120(1):72-82. http://dx.doi.org/10.1016/j.jbiotec.2005.03.026
  5. Teixeira A, Cunha AE, Clemente JJ, Moreira JL, Cruz HJ, Alves PM, Carrondo MJ, Oliveira R, 2005. Modelling and optimization of a recombinant BHK-21 cultivation process using hybrid grey-box systems. J Biotechnol, 118:290-303. http://dx.doi.org/10.1016/j.jbiotec.2005.04.024
  6. Oliveira R, Clemente JJ, Cunha AE, Carrondo MJ, 2005. Adaptive dissolved oxygen control through the glycerol feeding in a recombinant Pichia pastoris cultivation in conditions of oxygen transfer limitation. J Biotechnol, 116(1):35-50. http://dx.doi.org/10.1016/j.jbiotec.2004.09.016
  7. Ferreira TB, Alves PM, Aunins JG, Carrondo MJ, 2005. Use of adenoviral vectors as veterinary vaccines. Gene Ther, 12(S1):73-83. http://dx.doi.org/10.1038/sj.gt.3302618
  8. Fonseca LL, Monteiro MA, Alves PM, Carrondo MJ, Santos H, 2005. Cultures of rat astrocytes challenged with a steady supply of glutamate: a new model to study flux distribution in the glutamate-glutamine cycle. Glia, 51:286-96. http://dx.doi.org/10.1002/glia.20209
  9. Santos SS, Fonseca LL, Monteiro MA, Carrondo MJ, Alves PM,  2005. Culturing primary brain astrocytes under fully controlled environment in a novel bioreactor. J Neurosci Res, 79:26-32. http://dx.doi.org/10.1002/jnr.20279
  10. Souza AP, Peixoto CC, Maranga L, Carvalhal AV, Moraes RH, Mendonça RZ, Pereira CA, Carrondo MJ, Mendonça RZ, 2005. Purification and characterization of an anti-apoptotic protein isolated from Lonomia obliqua Hemolymph. Biotechnol Prog, 21:99-105. http://dx.doi.org/10.1021/bp049831p
  11. Monteiro SM, Clemente JJ, Henriques AO, Gomes RJ, Carrondo MJ, Cunha AE, 2005. A procedure for high-yield spore production by Bacillus subtilis. Biotechnol Prog, 21(4):1026-31. http://dx.doi.org/10.1021/bp050062z
  12. Ferreira TB, Ferreira AL, Carrondo MJ, Alves PM, 2005. Two different serum-free media and osmolality effect upon human 293 cell growth and adenovirus production. Biotechnol Lett, 27(22): 1809-13. http://dx.doi.org/10.1007/s10529-005-3558-z
  13. Kreij K, Mandenius CF, Clemente JJ, Cunha AE, Monteiro SM, Carrondo MJ, Hesse F, de Los Molinas MM, Wagner R, Merten OW, Gény-Fiamma C, Leger W, Wiesinger-Mayr H, Müller D, Katinger H, Mårtensson P, Bachinger T, Mitrovics J, 2005. On-line detection of microbial contaminations in animal cell reactor cultures using an electronic nose device. Cytotechnology, 48(1-3):41-58. http://dx.doi.org/10.1007/s10616-005-3587-4

2004

  1. Carrondo MJ, Aunins JG, 2004. Biochemical engineering. Curr Opin Biotechnol, 15(5):441-3. http://dx.doi.org/10.1016/j.copbio.2004.08.014
  2. Cunha AE, Clemente JJ, Gomes R, Pinto F, Thomaz M, Miranda S, Pinto R, Moosmayer D, Donner P, Carrondo MJ, 2004. Methanol induction optimization for scFv antibody fragment production in Pichia pastoris. Biotechnol Bioeng, 86(4):458-67. http://dx.doi.org/10.1002/bit.20051
  3. Carmo M,  Peixoto CC, Coroadinha AS, Alves PM, Cruz PE, Carrondo MJ, 2004. Quantitation of MLV-based retroviral vectors using real-time RT-PCR. J Virol Methods, 119:115-9. http://dx.doi.org/10.1016/j.jviromet.2004.03.007
  4. Maranga L, Cunha A, Clemente J, Cruz PE, Carrondo MJ, 2004. Scale-up of virus-like particles production: effects of sparging, agitation and bioreactor scale on cell growth, infection kinetics and productivity. J Biotechnol, 107:55-64. http://dx.doi.org/10.1016/j.jbiotec.2003.09.012

2003

  1. Carvalhal AV, Marcelino I, Carrondo MJ, 2003. Metabolic changes during cell growth inhibition by p27 overexpression. Appl Microbiol Biotechnol, 63:164-73. http://dx.doi.org/10.1007/s00253-003-1385-5
  2. Carvalhal AV, Santos SS, Calado J, Haury M, Carrondo MJ, 2003. Cell growth arrest by nucleotides, nucleosides and bases as a tool for improved production of recombinant proteins. Biotechnol Prog, 19:69-83. http://dx.doi.org/10.1021/bp0255917
  3. Maranga L, Brazão TF, Carrondo MJ, 2003. Virus like particles production at low multiplicities of infection with the baculovirus insect cell system. Biotechnol  Bioeng, 84:245-53. http://dx.doi.org/10.1002/bit.10773
  4. Maranga L, Mendonca RZ, Bengala A, Peixoto CC, Moraes RH, Pereira CA, Carrondo MJ, 2003. Enhancement of Sf-9 cell growth and longevity through supplementation of culture medium with hemolymph. Biotechnol Prog, 19:58-63. http://dx.doi.org/10.1021/bp025583q

2002

  1. Carvalhal A, Coroadinha AS, Alves PM, Moreira JL, Hauser H, Carrondo MJ, 2002. Metabolic changes during cell growth inhibition by the IRF-1 system. Enzyme Microb Technol, 30:95-109. http://dx.doi.org/10.1016/S0141-0229(01)00460-4
  2. Maranga L, Rueda P, Antonis AF, Vela C, Langeveld JP, Casal JI, Carrondo MJ, 2002. Large scale production and downstream processing of a recombinant porcine parvovirus vaccine. Appl Microbiol Biotechnol, 59:45-50. http://dx.doi.org/10.1007/s00253-002-0976-x
  3. Cruz HJ, Conradt HS, Dunker R, Peixoto CM, Cunha AE, Thomaz M, Burger C, Dias EM, Clemente J, Moreira JL, Reike E, Carrondo MJ, 2002. Process development of a recombinant antibody/interleukin-2 fusion protein expressed in protein-free medium by BHK cells. J Biotechnol, 96:169-83. http://dx.doi.org/10.1016/S0168-1656(02)00028-7
  4. Cruz PE, L Maranga, MJ Carrondo, 2002. Integrated process optimization: lessons from retrovirus and virus-like particle production. J Biotechnol, 99:199-214. http://dx.doi.org/10.1016/S0168-1656(02)00210-9
  5. Maranga L, AS Coroadinha, MJ Carrondo, 2002. Insect cell culture medium supplementation with fetal bovine serum and bovine serum albumin: effects on baculovirus adsorption and infection kinetics. Biotechnol Prog, 18:855-61. http://dx.doi.org/10.1021/bp025514b
  6. Maranga L, PE Cruz, JG Aunins, MJ Carrondo, 2002. Production of core and virus-like particles with baculovirus infected insect cells. Adv Biochem Eng Biotechnol, 74:183-206. http://dx.doi.org/10.1007/3-540-45736-4_9
  7. Lopes Mde F, Leitão AL, Regalla M, Marques JJ, Carrondo MJ, Crespo MT, 2002. Characterization of a highly thermostable extracellular lipase from Lactobacillus plantarum. Int J Food Microbiol, 76(1-2):107-15. http://dx.doi.org/10.1016/S0168-1605(02)00013-2

2001

  1. Carvalhal AV, Moreira JL, Carrondo MJ, 2001. Strategies to modulate BHK cell proliferation by the regulation of IRF-1 expression. J Biotechnol, 92:47-59. http://dx.doi.org/10.1016/S0168-1656(01)00365-0
  2. Fonseca LL, Alves PM, Carrondo MJ, Santos H, 2001. Effect of ethanol on the metabolism of primary astrocytes studied by [13C]- and [31P]-NMR spectroscopy. J Neurosci Res, 66:803-11. http://dx.doi.org/10.1002/jnr.10039
  3. Merten OW, Cruz PE, Rochette C, Geny-Fiamma C, Bouquet C, Goncalves D, Danos O, Carrondo MJ, 2001. Comparison of different bioreactor systems for the production of high titer retroviral vectors. Biotechnol Prog, 17:326-35. http://dx.doi.org/10.1021/bp000162z
  4. Morais VA, Serpa J, Palma AS, Costa T, Maranga L, Costa J, Wu N, Ataai MM, 2001. Expression and characterization of recombinant human alpha-3/4-fucosyltransferase III from Spodoptera frugiperda (Sf9) and Trichoplusia ni (Tn) cells using the baculovirus expression system. Biochem J, 353:719-25. http://www.biochemj.org/bj/353/bj3530719.htm

2000

  1. Alves PM, Fonseca LL, Peixoto CC, Almeida AC, Carrondo MJ, Santos H, 2000. NMR studies on energy metabolism of immobilized primary neurons and astrocytes during hypoxia, ischemia and hypoglycemia. NMR Biomed, 13:438-48. http://dx.doi.org/10.1002/nbm.665
  2. Alves PM, Nunes R, Zhang C, Maycock CD, Sonnewald U, Carrondo MJ, Santos H, 2000. Metabolism of 3-[13C]malate in primary cultures of mouse astrocytes. Dev Neurosci, 22:456-62. http://dx.doi.org/10.1159/000017475
  3. Cruz HJ, Peixoto CM, Nimtz M, Alves PM, Dias EM, Moreira JL, Carrondo MJ, 2000. Metabolic shifts do not influence the glycosylation patterns of a recombinant fusion protein expressed in BHK cells. Biotechnol Bioeng, 69:129-39. http://dx.doi.org/10.1002/(SICI)1097-0290(20000720)69:2<129::AID-BIT2>3.0.CO;2-5
  4. Araujo C, Marques S, Carrondo MJ, Gonçalves L, 2000. In vitro response of brown bullhead catfish (BB) and rainbow trout (RTG-2) cell lines to benzo[a]pyrene. Sci Total Environ, 247:127-35. http://dx.doi.org/10.1016/S0048-9697(99)00484-2
  5. Cruz HJ, Freitas CM, Alves PM, Moreira JL, Carrondo MJ, 2000. Effects of ammonia and lactate on growth, metabolism, and productivity of BHK cells. Enzyme Microb Technol, 27:45-52. http://dx.doi.org/10.1016/S0141-0229(00)00151-4
  6. Cruz HJ, Moreira JL, Carrondo MJ, 2000. Metabolically optimised BHK cell fed-batch cultures. J Biotechnol, 80:109-18. http://dx.doi.org/10.1016/S0168-1656(00)00254-6
  7. Cruz PE, Almeida JS, Murphy PN, Moreira JL, Carrondo MJ, 2000. Modeling retrovirus production for gene therapy. 1. Determination of optimal bioreaction mode and harvest strategy. Biotechnol Prog, 16:213-21. http://dx.doi.org/10.1021/bp9901466
  8. Cruz PE, Goncalves D, Almeida J, Moreira JL, Carrondo MJ, 2000. Modeling retrovirus production for gene therapy. 2. Integrated optimization of bioreaction and downstream processing. Biotechnol Prog, 16:350-57. http://dx.doi.org/10.1021/bp000017l
  9. Cruz PE, Peixoto CC, Devos K, Moreira JL, Saman E, Carrondo MJ, 2000. Characterization and downstream processing of HIV-1 core and virus-like-particles produced in serum free medium. Enzyme Microb Technol, 26:61-70. http://dx.doi.org/10.1016/S0141-0229(99)00128-3
  10. Cruz HJ, Dias EM, Peixoto CM, Moreira JL, Carrondo MJ, 2000. Product quality of a recombinant fusion protein expressed in immobilised baby hamster cells grown in protein-free medium. Biotechnol Lett, 22:677-82. http://dx.doi.org/10.1023/A:1005631602517
  11. Carvalhal AV, Moreira JL, Cruz H, Mueller P, Hauser H, Carrondo MJ, 2000. Manipulation of culture conditions for BHK cell growth inhibition by IRF-1 activation. Cytechnology, 32:135-45. http://dx.doi.org/10.1023/A:1008139304964

1999

  1. Cruz HJ, JL Moreira, MJ Carrondo, 1999. Metabolic shifts by nutrient manipulation in continuous cultures of BHK cells. Biotechnol Bioeng, 66:104-13. http://dx.doi.org/10.1002/(SICI)1097-0290(1999)66:2%3C104::AID-BIT3%3E3.3.CO;2-R
  2. Cruz PE, Martins PC, Alves PM, Peixoto CC, Santos H, Moreira JL, Carrondo MJ,  1999. Proteolytic activity in infected and non infected insect cells: degradation of HIV-1 Pr55gag particles. Biotechnol Bioeng, 65:133-43. http://dx.doi.org/10.1002/(SICI)1097-0290(19991020)65:2%3C133::AID-BIT2%3E3.0.CO;2-X
  3. Burger C, Carrondo MJ, Cruz H, Cuffe M, Dias E, Griffiths JB, Hayes K, Hauser H, Looby D, Mielke C, Moreira JL, Rieke E, Savage AV, Stacey GN, Welge T, 1999. An integrated strategy for the process development of a recombinant antibody-cytokine fusion protein expressed in BHK cells. Appl Microbiol Biotechnol, 52:345-53. http://dx.doi.org/10.1007/s002530051530
  4. Cruz HJ, Ferreira AS, Freitas CM, Moreira JL, Carrondo MJ, 1999. Metabolic responses to different glucose and glutamine levels in baby hamster kidney cell culture. Appl Microbiol Biotechnol, 51: 579-85. http://dx.doi.org/10.1007/s002530051435
  5. Silva Lopes Mde F, Leitão AL, Marques JJ, Carrondo MJ, Crespo MT, 1999. Processing of extracellular lipase of Lactobacillus plantarum: involvement of a metalloprotease. FEMS Microbiol Lett, 176(2):483-7. http://dx.doi.org/10.1111/j.1574-6968.1999.tb13701.x
  6. Lopes Mde F, Cunha AE, Clemente JJ, Carrondo MJ, Crespo MT, 1999. Influence of environmental factors on lipase production by Lactobacillus plantarum. Appl Microbiol Biotechnol, 51(2):249-54. http://dx.doi.org/10.1007/s002530051389

1998

  1. Cruz PE, Peixoto CC, Moreira JL, Carrondo MJ, 1998. Optimization of the production of virus-like particles in insect cells. Biotechnol Bioeng, 60:408-18. http://dx.doi.org/10.1002/(SICI)1097-0290(19981120)60:4<408::AID-BIT2>3.0.CO;2-Q
  2. Cruz PE, Peixoto CC, Moreira JL, Carrondo MJ, 1998. Production and quality analysis of Pr55gag particles produced in baculovirus-infected insect cells. J Chem Technol Biotechnol, 72:149-58. http://dx.doi.org/10.1002/(SICI)1097-4660(199806)72:2%3C149::AID-JCTB886%3E3.3.CO;2-3
  3. Cruz HJ, Moreira JL, Stacey G, Dias EM, Hayes K, Looby D, Griffiths B, Carrondo MJ, 1998. Adaptation of BHK cells producing a recombinant protein to serum-free media and protein-free medium. Cytotechnology, 26:59-64. http://dx.doi.org/10.1023/A:1007951813755

1997

  1. Cruz HJ, Dias EM, Moreira JL, Carrondo MJ, 1997. Cell-dislodging methods under serum-free conditions. App Microbiol Biotechnol, 47:482-88. http://dx.doi.org/10.1007/s002530050960
  2. Cruz PE, Moreira JL, Carrondo MJ, 1997. Insect cell growth evaluation during serum-free adaptation in stirred suspension cultures. Biotechnol Tech, 11:117-20. http://dx.doi.org/10.1023/B:BITE.0000034015.83434.66

1996

  1. Alves PM, JL Moreira, JM Rodrigues, JG Aunins, MJ Carrondo, 1996. Two-dimensional versus three-dimensional culture systems: effects on growth and productivity of BHK cells. Biotechnol Bioeng, 52:429-32. http://dx.doi.org/10.1002/(SICI)1097-0290(19961105)52:3<429::AID-BIT9>3.0.CO;2-M
  2. Alves PM, Moreira JL, Rodrigues JM, Aunins JG, Carrondo MJ, 1996. Immobilization of primary astrocytes and neurons for on-line monitoring of biochemical processes by NMR. Dev Neurosci, 18:478-83. http://dx.doi.org/10.1159/000111443
  3. Kirchhoff S, Kröger A, Cruz H, Tümmler M, Schaper F, Köster M, Hauser H, 1996. Regulation of cell growth by IRF-1 in BHK-21 cells. Cytotechnology, 22:147-56. http://dx.doi.org/10.1007/BF00353934

1995

  1. Alves PM, MC Mckenna, U Sonnewald, 1995. Lactate metabolism in mouse brain astrocytes studied by [13C]NMR spectroscopy. NeuroReport, 6:2201-04. http://www.ncbi.nlm.nih.gov/pubmed/8595202
  2. Moreira JL, Alves PM, Aunins JG, Carrondo MJ, 1995. Hydrodynamic effects on BHK cells grown as suspended natural aggregates. Biotechnol Bioeng, 46:351-60. http://dx.doi.org/10.1002/bit.260460408
  3. Moreira JL, Alves PM, Feliciano A, Aunins JG, Carrondo MJ, 1995. Serum-free and serum-containing media for growth of suspended BHK aggregates in stirred vessels. Enzyme Microb Tech, 17:437-44. http://dx.doi.org/10.1016/0141-0229(94)00071-X
  4. Moreira JL, Cruz PE, Santana P, Aunins JG, Carrondo MJ, 1995. Formation and disruption of animal cell aggregates in stirred vessels: mechanisms and kinetic studies. Chem Eng Sci, 50:2747-64. http://dx.doi.org/10.1016/0009-2509(95)00118-O
  5. Moreira JL, Santana PC, Feliciano AS, Cruz PE, Racher AJ, Griffiths JB, Carrondo MJ, 1995. Effect of viscosity upon hydrodynamically controlled natural aggregates of animal cells grown in stirred vessels. Biotechnol Prog, 11:575-83. http://dx.doi.org/10.1021/bp00035a012
  6. Xavier AL, Gonçalves J, Moreira JL, Carrondo MJ, 1995. Operational patterns affecting lactic acid production in ultrafiltration cell recycle bioreactor. Biotechnol Bioeng, 45:320-27. http://dx.doi.org/10.1002/bit.260450406
  7. Almeida JS, Reis MA, Carrondo MJ, 1995. Competition between nitrate and nitrite reduction in denitrification by Pseudomonas fluorescens. Biotechnol Bioeng, 46(5):476-84. http://dx.doi.org/10.1002/bit.260460512
  8. Almeida JS, Júlio SM, Reis MA, Carrondo MJ, 1995. Nitrite inhibition of denitrification by Pseudomonas fluorescens. Biotechnol Bioeng, 46(3):194-201. http://dx.doi.org/10.1002/bit.260460303

1994

  1. Moreira JL, Alves PM, Aunins JG, Carrondo MJ, 1994. Changes in animal cell natural aggregates in suspended batch cultures. Appl Microbiol Biotechnol, 41: 203-9. http://dx.doi.org/10.1007/BF00186960
  2. Moreira JL, Alves PM, Rodrigues JM, Cruz PE, Aunins JG, Carrondo MJ, 1994. Studies of baby hamster kidney natural cell aggregation in suspended batch cultures. Ann N Y Acad Sci, 745:122-33. http://dx.doi.org/10.1111/j.1749-6632.1994.tb44368.x
  3. Moreira JL, Feliciano AS, Santana PC, Cruz PE, Aunins JG, Carrondo MJ, 1994. Repeated-batch cultures of baby hamster kidney cell aggregates in stirred vessels. Cytotechnology, 15:337-49. http://dx.doi.org/10.1007/BF00762409
  4. Racher AJ, Moreira JL, Alves PM, Wirth M, Weidle UH, Hauser H, Carrondo MJ, Griffiths JB, 1994. Expression of recombinant antibody and secreted alkaline phosphatase in mammalian cells. Influence of cell line and culture system upon production kinetics. Appl Microbiol Biotechnol, 40:851-6.  http://dx.doi.org/10.1007/BF00173987

1992

  1. Reis MA, Almeida JS, Lemos PC, Carrondo MJ, 1992. Effect of hydrogen sulfide on growth of sulfate reducing bacteria. Biotechnol Bioeng, 40(5):593-600. http://dx.doi.org/10.1002/bit.260400506
  2. Moreira JL, Wirth M, Fitzek M, Hauser H, 1992. Evaluation of reporter genes in mammalian cell lines. Meth Mol Cell Biol, 3:23-2.

1990

  1. Crespo JP, Almeida JS, Moura MJ, Carrondo MJ, 1990. Modeling of immobilized cell reactor for propionic acid fermentation. Biotechnol Bioeng, 36(7):705-16. http://dx.doi.org/10.1002/bit.260360708

1984

  1. Carrondo MJ, Reboredo F, Ganho RM, Oliveira JF, 1984. Analysis of sediments for heavy metals by a rapid electrothermal atomic-absorption procedure. Talanta, 31(7):561-4. http://dx.doi.org/10.1016/0039-9140(84)80141-1

1979

  1. Carrondo MJ, Lester JN, Perry R, 1979. An investigation of a flameless atomic-absorption method for determination of aluminium, calcium, iron and magnesium in sewage sludge. Talanta, 26(10):929-33. http://dx.doi.org/10.1016/0039-9140(79)80128-9

 

 

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