Personal tools
You are here: Home / Labs / Animal Cell Technology Unit / Publications / PhD Theses
 

PhD Theses

Last update: 09-12-2022

2022

  • João Mendes, Integrated Continuous Manufacturing of Adeno-associated virus. Supervisors: Cristina Peixoto and Ricardo Silva.

  • Francisca Arez, Advancing liver-stage Malaria in vitro models for drug discovery. Supervisors: Paula Alves and Miguel Prudêncio. https://hdl.handle.net/10362/143171

  • Ana Filipa Louro, Cell-Based and cell-free strategies for cardiac repair. Supervisors: Margarida Serra. https://hdl.handle.net/10362/143165

  • Rita Mendes, Harnessing complex metabolic signatures to predict drug efficacy in ovarian cancer. Supervisors: Inês Isidro and Catarina Brito. https://hdl.handle.net/10362/143167

  • Jorge Moura Sampaio, Structurally Primed Antibody Libraries. Supervisors: Ana Batista and Paula Alves. https://hdl.handle.net/10362/145703

  • Bárbara Dias Fernandes, Bioprocess Engineering of Insect Cells for Accelerating Vaccines Development. Supervisors: António Roldão and Manuel Carrondo. https://hdl.handle.net/10362/141656
  • Ricardo Correira, Atypical culture conditions and process intensification to enhance vaccine production using insect cells. Supervisors: António Roldão and Manuel Carrondo. https://hdl.handle.net/10362/141657

2021

  • Catarina Benavente Perdigão, The impact of the genetic risk factor BIN1 on Alzheimer’s disease development. Supervisors: Cláudia Guimas Almeida and Catarina Brito. https://hdl.handle.net/10362/132008
  • Teresa Maria Franchi Mendes, Three-dimensional culture approaches to advance the representation of the tumour microenvironment in preclinical and translational research. Supervisors: Catarina Brito and Isadora Rosa.
  • Joana Sales Dias, Developing of novel therapeutics for breast cancer: targeting the Notch ligand DLL1. Supervisors: Ana Barbas and Tiago Bandeiras. https://hdl.handle.net/10362/121639

2020

  • Daniel Pais, Development of advanced monitoring and control tools for rAAV production in the insect cell system. Supervisors: Paula M. Alves and Inês Isidro. https://hdl.handle.net/10362/97879
  • João Sá, Metabolic systems biology for stem cell bioprocesses. Supervisors: Manuel Carrondo and Inês Isidro. https://hdl.handle.net/10362/96830
  • Ana Sofia Formas-Oliveira, Improving y-retrovirus and lentivirus gene therapy vectors: From producer cell engineering to transduction performance. Supervisor: Ana Sofia Coroadinha. https://hdl.handle.net/10362/102210
  • Marcos Filipe Quintino de Sousa, Streamlining upstream processing of complex biopharmaceuticals. Supervisors: António Roldão and Manuel Carrondo. https://hdl.handle.net/10362/107270
  • Ana Luísa Cartaxo, Tumor microenvironment models: ex vivo, in vitro and in silico approaches to address targeted therapies. Supervisor: Catarina Brito. https://hdl.handle.net/10362/105645
  • Mafalda Marques Dias, Engineering stable insect cell expression systems using site-specific integration technology for production of complex proteins. Supervisors: António Roldão and Ana Teixeira. https://hdl.handle.net/10362/109492

2019

  • Hélio Antunes Tomás, Development of novel HIV-1 based lentiviral vector producer cells. The impact of mutated T26S HIV-1 protease in lentiviral vector production. Supervisors: Ana Sofia Coroadinha and Manuel Carrondo
  • Sofia Abreu, Development of cell models for translational research. Supervisors: Catarina Brito
  • Miguel R. Guerreiro, Cell-based switch-on sensors for detection and quantification of label-free viruses. Supervisors: Ana Sofia Coroadinha. https://hdl.handle.net/10362/93882
  • Mafalda Moleirinho, Advancing purification of biotherapeutic particles: Exploiting new materials and operation modes. Supervisors: Cristina Peixoto and Ricardo Silva

2018

  • Sofia Carvalho, Downstream strategies for VLPs as candidate universal vaccine for Influenza. Supervisors: Manuel JT Carrondo and Cristina Peixoto. https://hdl.handle.net/10362/93880
  • Hugo Ricardo Loureiro Soares, Viral and cell host factors influencing the development of an HCV vaccine candidate. Supervisors: Ana Sofia Coroadinha and Paula M. Alves.
  • Marta Estrada, Novel cell models to study breast tumour microenvironment and disease progression. Supervisors: Catarina Brito and Paula M. Alves. https://hdl.handle.net/10362/93879
  • Marta Sofia Marques Silva, Stem cell bioengineering strategies for cardiac regeneration: Unveiling CCBE1 role as a modulator of cardiomyocyte differentiation. Supervisors: Paula M. Alves and José A. Belo. https://hdl.handle.net/10362/98058
  • Maria João Sebastião, Towards novel stem cell and protein based therapies for myocardium regeneration: Exploiting myocardial ischemia/reperfusion models and advanced proteomic. Supervisors: Paula M. Alves, Margarida Serra e Patrícia Gomes Alves. https://hdl.handle.net/10362/98059
  • Bernardo Martins da Cunha Abecasis, Engineering human in vitro cardiac tissue models for preclinical research. Supervisors: Paula M. Alves and Lino Ferreira
  • Ana Catarina Pereira Pinto, Targeting Cancer Vulnerabilities: from molecular targets to antitumor immunity. Supervisors: Paula M. Alves and Catarina Brito. https://hdl.handle.net/10362/93876
  • Ana Paula Barreto Terrasso, Neural cell models for disease modeling and drug discovery: exploiting 3D differentiation of human stem cells. Supervisors: Catarina Brito and Cláudia Almeida. https://hdl.handle.net/10362/98065

2017

  • Cláudia Susana Pedreira Correia, Bioprocessing of human Pluripotent Stem Cells for cardiac cell therapy and pre-clinical research. Supervisors: Paula M. Alves and Margarida Serra. https://hdl.handle.net/10362/20446

2016

  • Bárbara Martins Paiva da Cunha, Development of Integrated Strategies for the Downstream Processing of Human Stem Cells for Clinical Application. Supervisors: Margarida Serra, Cristina Peixoto and Paula Alves. https://hdl.handle.net/10362/20208
  • Tiago Martins da Costa Duarte, Probing CHO cells using metabolomics and fluxomics tools. Supervisors: Paula Alves and Ana Teixeira. https://hdl.handle.net/10362/55746
  • Ana Sofia Cabral e Sousa de Almeida, Carbon monoxide modulation of neuronal diffentiation – disclosing celular mechanisms. Supervisors: Helena Vieira and Paula Alves. https://hdl.handle.net/10362/56700
  • Daniel Filipe Mestre Simão, Development of human central nervous system 3D in vitro models for preclinical research. Supervisors: Paula M. Alves and Catarina Brito. https://hdl.handle.net/10362/17094
  • Ana Carina Santos Ferreira da Silva, Strategies for improved Adenovirus and PPR vaccine production in different cell lines: from bioprocess development to final formulation. Supervisors: Paula Alves and Pedro Cruz. https://hdl.handle.net/10362/20519

2015

  • Ricardo Perdigão Henriques, The role of the miR-200 family in the epithelial-to-mesenchymal transition (EMT). Supervisor: Manuel JT Carrondo. https://hdl.handle.net/10362/20499
  • Francisca Monteiro, Rational design of insect cell-based vaccine production: Bridging metabolomics with mathematical tools to study virus-host interactions. Supervisors: Paula M. Alves and Vicente Bernal. https://hdl.handle.net/10362/20494
  • Piergiuseppe Nestola, Improving downstream processing for viral vectors and viral vaccines. Supervisor: Manuel JT Carrondo. https://hdl.handle.net/10362/14845
  • Sofia Rebelo, Development of 3D in vitro models for prediction of hepatic metabolism and toxicology. Supervisors: Paula M. Alves and Catarina Brito. https://hdl.handle.net/10362/15268
  • Fabiana Fernandes, Establishment and evaluation of a flexible insect cell line for rapid production of recombinant proteins. Supervisors: Paula M. Alves, Ana Teixeira and Kristala Prather, MIT. https://hdl.handle.net/10362/15270
  • Paulo Fernandes, Bioprocess design of canine adenovírus vectors for gene therapy applications. Supervisors: Paula M. Alves and Ana Sofia Coroadinha. https://hdl.handle.net/10362/14842

2014

  • Ana Filipa Rodrigues, Integrated functional genomics for improved manufacture of recombinant enveloped virus: transcriptional profiling and metabolic engineering of retrovirus producer cells. Supervisors: Wei-Shou Hu and Ana Sofia Coroadinha. https://hdl.handle.net/10362/11972

2012

  • Joana Lamego, Understanding Human Carboxylesterase 2 – and the feasibility of a more relevant cell model for intestinal metabolism. Supervisors: Ana Luísa Simplício and Ana Sofia Coroadinha. https://hdl.handle.net/10362/10510
  • Cláudia Queiroga, Disclosing Carbon Monoxide Protection in Cerebral Ischemia – Insight into the cellular mechanisms. Supervisors: Helena L.A. Vieira and Paula M. Alves. https://hdl.handle.net/10362/10869
  • Sofia Batista Leite, Novel Approaches for Culturing Hepatocytes for Drug Testing Applications.  Supervisors: Paula M. Alves. https://hdl.handle.net/10362/8555
  • Rui Tostões, Process Engineering of Liver Cells for Drug Testing Applications. Supervisors: Paula M. Alves. https://hdl.handle.net/10362/7612

2011

2010

  • Tiago Vicente, Downstream processing development of enveloped viruses for clinical applications – Innovative tools for rational process optimization. Supervisors: Manuel J. T. Carrondo and Paula M. Alves. https://hdl.handle.net/10362/5247
  • António Roldão, Production Optimization of Rotavirus-Like Particles - A Systems Biology Approach. Supervisors: Rui M. F. Oliveira and Manuel J. T. Carrondo. https://hdl.handle.net/10362/5246
  • Leonor Norton, Expression of Antibodies and Retroviral Vectors from Defined Chromosomal Sites: Strategies towards Reliable Production Systems, 2010. Supervisors: Hansjörg Hauser and Paula M. Alves. https://hdl.handle.net/10362/5770
  • Rita Malpique, Novel Cryopreservation Strategies for Cell Therapies and Pre-Clinical Research. 2010. Supervisors: Paula M. Alves and Heiko Zimmermann. https://hdl.handle.net/10362/14122

2009

  • Sónia Sá Santos, In Vitro Models for Metabolic Studies of Brain Insults. Supervisor: Paula M. Alves
  • Candida Mellado, Triple-layered rotavirus-like particles production: a focus on in vitro assembly and disassembly. Supervisors: Paula M. Alves and Manuel J. T. Carrondo
  • Marlene Carmo, Gammaretroviral and Lentiviral Vectors for Gene Therapy – Stability and Inactivation Mechanisms. Supervisors: Manuel J.T. Carrondo and Pedro Cruz. https://hdl.handle.net/10362/5241
  • Cristina C. Peixoto: Challenges in the Purification of Complex Biopharmaceuticals. Supervisor: Paula M. Alves

2008

  • Ana Margarida Teixeira, Bridging Systems Biology and Bioprocess Engineering: Application to Mammalian cell cultures. Supervisors: Rui M.F. Oliveira and. Manuel J.T. Carrondo
  • Teresa Rodrigues, Purification of Retroviral Vectors for Gene Therapy. Supervisors: Pedro Cruz and. Manuel J.T. Carrondo

2007

  • Claudia Istrate, Host and Immune Response to Natural and Experimental Rotavirus Infection. Supervisors: Manuel J.T. Carrondo and Paula M. Alves
  • Tiago Bruno Ferreira, Adenovirus as a Biopharmaceutical: Optimisation of Vector Production. Supervisors: Paula M. Alves and. Manuel J.T. Carrondo. https://hdl.handle.net/10362/73622
  • Isabel Eloi Marcelino, Development of a Vaccine Candidate Against Heartwater: Producing Obligate Intracellular Bacteria for Veterinary Application. Supervisors:. Manuel J.T. Carrondo and Paula M. Alves

2005

  • Ana Sofia Coroadinha, Improved Strategies for the Development of Retroviral Gene Therapy Vectors: From the Producer Cell to the Viral Vector, 2005. Supervisor: Manuel J.T. Carrondo

2003

  • Luis Camilo Maranga, Engineering Challenges in the Production of VLPs: Understanding Baculovirus-Insect Cells Interactions, 2003. Supervisor:. Manuel J.T. Carrondo
  • Ana Verónica Carvalhal, Mammalian Cell Growth Arrest for Biopharmaceutical Production Improvement, 2003. Supervisor: Manuel J.T. Carrondo

2001

  • Paula M. Alves, NMR Studies of Central Metabolism in Brain Cells, Immobilized Primary Cultures as Model-System, 2001. Supervisors:. Helena Santos and Manuel J.T. Carrondo

1999

  • Helder J. S. Cruz, Modulation of BHK Cell Metabolism by Nutrient Manipulation. 1999. Supervisor: Manuel J.T. Carrondo
  • Pedro E. Cruz, Global Optimization of Bioprocesses: A focus on Complex Bioproducts. 1999. Supervisor: Manuel J.T. Carrondo

1994

  • José L. Moreira, Engineering of Animal Cell Aggregates. 1994. Supervisor: Manuel J.T. Carrondo
Document Actions