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Laboratory of Glycobiology

In the Laboratory of Glycobiology we aim at an integrated view of protein glycosylation in homeostasis and disease.

Major topics of research include:

1) Characterization of protein glycosylation from human cells, biofluids and extracellular vesicles with relevance in neurodegeneration using Glycomics methodologies to unveil novel biomarkers and therapeutic targets.

 

Selected publications:

Sandau et al (2024) Recommendations for Reproducibility of Cerebrospinal Fluid Extracellular Vesicle Studies. J. Extracel. Ves. 13:12397. doi: 10.1002/jev2.12397.

Costa et al (2023) Protein glycosylation and glycoinformatics for novel biomarker discovery in neurodegenerative diseases. Aging Res. Rev. 89, 101991. https://doi.org/10.1016/j.arr.2023.101991. 

Castro et al (2021) Production of high-quality SARS-CoV-2 antigens: impact of bioprocess and storage on glycosylation, biophysical attributes, and ELISA serologic tests performance. Biotech. Bioengineer. 118, 2202. doi: 10.1002/bit.27725

Costa et al (2020) Investigating LGALS3BP/90K glycoprotein in the cerebrospinal fluid of patients with neurological diseases. Sci. Rep. 10, 5649. doi: 10.1038/s41598-020-62592-w.

Costa et al (2019) Exploring Cerebrospinal Fluid IgG N-Glycosylation as Potential Biomarker for Amyotrophic Lateral Sclerosis. Molecular Neurobiol. 56, 5729. doi: 10.1007/s12035-019-1482-9.

Costa et al (2018) N-Glycosylation of extracellular vesicles from HEK-293 and glioma cell lines. Anal Chem. 90, 7871. doi: 10.1021/acs.analchem.7b05455.

 

2) Characterization of mammalian glycosyltransferases with applications for in vitro synthetic approaches.

 

 

 

 

 

 

doi: 10.1038/s41598-023-48605-480

 

Selected publications:

Vicente et al (2023) Glycosyltransferase 8 domain-containing protein 1 (GLT8D1) is a UDP-dependent galactosyltransferase. Sci. Rep. 13:21684. doi: 10.1038/s41598-023-48605-480.

Gouveia et al (2012) Expression of glycogenes in differentiating human NT2N neurons. Downregulation of fucosyltransferase 9 leads to decreased Lewisx levels and impaired neurite outgrowth. BBA 1820, 2007. doi: 10.1016/j.bbagen.2012.09.004. 

 

3) Glycoproteins, glycans and extracellular vesicles to modulate gut microbiota for a healthy brain.

 

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