Publications
A. R. Nevesa, W. A. Pool, A. Solopova, J. Kok, H. Santos, O. P. Kuipers.Towards enhanced galactose utilization in Lactococcus lactis. A. R. Neves, W. A. Pool, A. Solopova, J. Kok, H. Santos & O. P. Kuipers. Appl. Environ. Microbiol. 76, 7048-7060 (2010) aCorresponding author.
S. Vinga, A. R. Neves, H. Santos, B. W. Brandt & S. A. L. M. Kooijman. 2010. Subcellular metabolic organization in the context of Dynamic Energy Budget and Biochemical Systems theories. Philos Trans R Soc Lond B Biol Sci. 365, 3429-3442 (2010).
K. Pokusaeva, A. R. Neves, A. Zomer, M. O’Connell-Motherway, J. MacSharry, P. Curley, G. F. Fitzgerald & D. van Sinderen. Ribose utilization by the human commensal Bifidobacterium breve UCC2003. Microb. Biotechnol. (2009; doi:10.1111/j.1751-7915.2009.00152.x).
H. Yesilkaya, F. Spissu, S. M. Carvalho, V. S. Terra, K. A. Homer, R. Benisty, N. Porat, A. R. Neves, and P. W. Andrew. Pyruvate formate lyase is required for pneumococcal permentative metabolism and virulence. Infect. Immun. 77, 5418–5427 (2009).
R. Castro, A. R. Nevesa, L. L. Fonseca, W. A. Pool, J. Kok, O. P. Kuipers & H. Santos. Characterization of the individual glucose uptake systems of Lactococcus lactis: mannose-PTS, cellobiose-PTS and the novel GlcU permease. Mol. Microbiol. 71, 795–806 (2009) aCorresponding author.
A. Z. Andersen, A. L. Carvalho, A. R. Neves, H. Santos, U. Kummer & L. F. Olsen. The metabolic pH response in Lactococcus lactis: an integrative experimental and modelling approach. Comput. Biol. Chem. 33, 71-83 (2009).
P. Gaspar, A. R. Neves, H. Santos, P. F. de Palencia, C. Pelaez, T. Requena. Engineering and re-routing of the metabolism of lactic acid bacteria. Pp. 265-289. B. Mayo, P. López & G. Pérez-Martínez, Editors. Molecular Aspects of Lactic Acid Bacteria for Traditional and New Applications. Research Signpost, Kerala (2008).
P. Gaspar, A. R. Neves, C. A. Shearman, M. J. Gasson, A. M. Baptista, D. L. Turner, C. M. Soares & H. Santos. The lactate dehydrogenases encoded by the ldh and ldhB genes in Lactococcus lactis exhibit distinct regulation and catalytic properties - comparative modeling to probe the molecular basis. The FEBS Journal, 274: 5924-5936 (2007). Pubmed ID: 17944947
C. Sánchez, A. R. Neves, J. Cavalheiro, M.M. dos Santos, N. García-Quintáns, P. López & H. Santos. The contribution of citrate metabolism to the growth of Lactococcus lactis CRL264 at low pH. Appl. Environ. Microbiol. 74, 1136-44 (2008). Pubmed ID: 18156322
C. Fonseca, A. R. Neves, A. M. M. Antunes, J. P. Noronha, B. Hahn‑Hägerdal, H. Santos & I. Spencer-Martins. Use of in vivo 13C nuclear magnetic resonance spectroscopy to elucidate L-arabinose metabolism in yeasts. Appl. Environ. Microbiol. 74, 1845–1855 (2008). Pubmed ID: 18245253
A. R. Neves, W. A. Pool, R. Castro, A. Mingote, F. Santos, J. Kok, O. Kuipers & H. Santos. The α-phosphoglucomutase of Lactococcus lactis is unrelated to the α-D-phosphohexomutase superfamily and encoded by the essential gene pgmH. Journal of Biological Chemistry. 281, 36864–36873 (2006). Pubmed ID: 16980299
E. O. Voit, J. Almeida, S. Marino, R. Lall, G. Goel, A. R. Neves & H. Santos. Regulation of glycolysis in Lactococcus lactis: an unfinished systems biological case study. Systems Biology (Stevenage). 153, 286-298 (2006). Pubmed ID: 16986630
W. A. Pool, A. R. Neves, J. Kok, H. Santos & O. Kuipers. Natural sweetening of food products by engineering Lactococcus lactis towards glucose production. Metabolic Engineering. 8, 456-464 (2006). Pubmed ID: 16844396
E. O. Voit, A. R. Neves & H. Santos. The Intricate Side of Systems Biology. Proceedings of the National Academy of Sciences USA. 103, 9452-9457 (2006). Pubmed ID: 16766654
A. R. Neves, W. A. Pool, J. Kok, O. Kuipers & H. Santos. Overview on sugar metabolism and its control in Lactococcus lactis – the input from in vivo NMR. FEMS Microbiology Reviews. 29, 531-554 (2005). Pubmed ID: 15939503
P. Gaspar, A. R. Neves, A. Ramos, M. J. Gasson, C. Shearman & H. Santos. Engineering Lactococcus lactis for the production of mannitol: high yields from food-grade strains deficient in lactate dehydrogenase and the mannitol transport pathway. Applied and Environmental Microbiology. 70, 1466-1474 (2004). Pubmed ID: 15006767
A. Ramos, A. R. Neves, R. Ventura, C. Maycock, P. López & H. Santos. The effect of overproduction of pyruvate kinase on glucose metabolism in Lactococcus lactis. Microbiology-SGM. 150, 1103-1111 (2004). Pubmed ID: 15073320
R. Anderson, M. Latorre-Esteves, A. R. Neves, S. Lavu, O. Medvedik, C. Taylor, K. T. Howitz, H. Santos & D. A. Sinclair. Yeast life-span extension by calorie restriction is independent of NAD+ fluctuation. Science. 302, 2124-2126 (2003). Pubmed ID: 14605207
A. Ramos, A. R. Neves & H. Santos. Metabolism of lactic acid bacteria studied by nuclear magnetic resonance. Antonie van Leeuwenhoek 82, 249-261 (2002). Pubmed ID: 12369191
A. R. Neves, A. Ramos, H. Costa, I. I. Van Swam, J. Hugenholtz, M. Kleerebezem, W. M. de Vos & H. Santos. Effect of different NADH oxidase levels on glucose metabolism by Lactococcus lactis: kinetics of intracellular metabolite pools determined by in vivo nuclear magnetic resonance. Appl. Environ. Microbiol. 68, 6332-6342 (2002). Pubmed ID: 12450858
A. R. Neves, A. Ramos, C. Shearman, M. J. Gasson & H. Santos. Catabolism of mannitol metabolism in Lactococcus lactis MG1363 and a mutant deficient in lactate dehydrogenase. Microbiology-SGM 148, 3467-3476 (2002). Pubmed ID: 12427938
A. R. Neves, R. Ventura, N. Mansour, C. Shearman, M. J. Gasson, C. Maycock, A. Ramos, & H. Santos. Is the glycolytic flux in Lactococcus lactis primarily controlled by the redox charge? Kinetics of NAD+ and NADH pools determined in vivo by 13C‑NMR. J. Biol. Chem. 277, 28088-28098 (2002). Pubmed ID: 12011086
A. R. Neves, A. Ramos & H. Santos. Mannitol production by a genetically modified Lactococcus lactis strain studied by 13C-NMR in situ. Pp. 75-81. G. A. Webb, P. S. Belton, A. M. Gil & I. Delgadilho, Editors. The Royal Society of Chemistry, Cambridge (2001).
A. R. Neves, A. Ramos, C. Shearman, M. J. Gasson, J. Almeida & H. Santos. Metabolic characterization of Lactococcus lactis deficient in lactate dehydrogenase using 13C-NMR. Eur. J. Biochem. 267, 3859-3868 (2000). Pubmed ID: 10849005
A. Ramos, A. R. Neves, J. S. Almeida & H. Santos. Ressonância Magnética Nuclear: uma técnica não-invasiva para observar em tempo real metabolitos em células vivas. Química, 77, 8-16 (2000).
A. R. Neves, A. Ramos, M. C. Nunes, M. Kleerebezem, J. Hugenholtz, W. M. de Vos, J. Almeida & H. Santos. In vivo NMR studies of glycolytic kinetics in Lactococcus lactis. Biotechnol. Bioeng. 64, 200-212 (1999). Pubmed ID: 10397856
I. L. Ferreira, C. B. Duarte, A. R. Neves & A. P. Carvalho. Culture medium components modulate retina cell damage induced by glutamate, kainate or “chemical ischemia”. Neurochem. Int. 32, 387-396 (1998). Pubmed ID: 9596563
