Publications
2005-2010
J. Moura, A.L. Simplício, "Electrophoretically mediated microanalysis for the evaluation of interspecies variation in cholinesterase metabolism", Electrophoresis, 31, 2010, available online. »
H. Serra, M.R. Bronze, A.L. Simplício, "Simultaneous determination of clopidogrel and its carboxylic acid metabolite by capillary electrophoresis", J. Chromatogr. B, 878 (2010), 1480-1486. »
Márquez JF, Radics G, Windle H, Serra HO, Simplicio AL, Fallon PG, Kelleher DP, Gilmer JF. "Design, Synthesis and Pharmacological Effects of a Cyclization Activated Steroid Prodrug for Colon Targeting in Inflammatory Bowel Disease", J. Med. Chem., 52 (2009) 3205-3211.
M. Jesus Perry, Eduarda Mendes, Ana Luísa Simplício, Ana Coelho, Jim Iley, Rui Moreira and Ana Paula Francisco "Dopamine- and tyramine-based derivatives of triazenes. Activation by tyrosinase and implications for prodrug design", Eur. J. Med Chem, 44 (2009) 3228-3234.
A.R. Sampaio de Sousa, Rodrigo Silva, Feng H. Tay, Ana Luísa Simplício, Sergei G. Kazarian, Catarina M.M. Duarte “Solubility enhancement of trans-chalcone using lipid carriers and supercritical CO2 processing” , J. Supercritical Fluids, 48 (2009) 120-125.
Carla A. Gamelas, Tiago Lourenço, André Pontes da Costa, Ana L. Simplício, Beatriz Royo, Carlos C. Romão, “Selective and mild oxidation of sulfides to sulfoxides or sulfones using H2O2 and Cp0Mo(CO)3Cl as catalysts”, Tetrahedron Lett. 49 (2008) 4708–4712.
Duarte AR, Simplicio AL, Vega-González A, Subra-Paternault P, Coimbra P, Gil MH, de Sousa HC, Duarte CM, "Impregnation of an intraocular lens for ophthalmic drug delivery", Curr Drug Del. 5 (2008) 102-7.
Maria Candida M Mellado, Catarina Franco, Ana Coelho, Paula M Alves, Ana Luísa Simplício, "Sodium dodecyl sulfate-capillary gel electrophoresis analysis of rotavirus-like particles" J. Chromatogr. A, 1192 (2008) 166-72. »
A.R. Sampaio de Sousa, Ana Luísa Simplício, Herminio C. de Sousa and Catarina M.M. Duarte, “Preparation of glyceryl monostearate based particles by PGSS® - application to caffeine”, J. Supercritical Fluids, 43 (2007) 120-125.
H. Serra, T. Mendes, M.R. Bronze and Ana Luísa Simplício, "Prediction of intestinal absorption and metabolism of pharmacologically active flavones and flavanones" Bioorg. Med. Chem., 16 (2008), 4009-4018. »
Ana L. Simplício, John M. Clancy and John F. Gilmer, "Prodrugs for Amines" Molecules 13 (2008) 519-547. »
Ana Rita C. Duarte, Ana Luísa Simplício, Arlette Vega-González, Pascale Subra-Paternault, Patrícia Coimbra, M.H. Gil, Hermínio C. de Sousa, Catarina M. M. Duarte, "Supercritical fluid impregnation of a biocompatible polymer for ophthalmic drug delivery", J. Supercritical Fluids, 42 (2007) 373-377.
Ana Luísa Simplício, John M. Clancy, John F. Gilmer, "ß-aminoketones as prodrugs with pH-controlled activation", Int. J. Pharm, 336 (2007) 208-214. »
Ana Luísa Simplício, Pedro Matias, John F. Gilmer, John M. Clancy, “Chiral separation and identification of b-aminoketones of pharmacological interest by HPLC and capillary electrophoresis”, J. Chromatogr. A, 1120 (2006) 89-93. »
Ana Rita C. Duarte, Teresa Casimiro, Ana Aguiar Ricardo, Ana Luísa Simplício, Catarina M. M. Duarte, "Supercritical Fluid Polymerisation and Impregnation of Molecularly Imprinted Polymers for Drug Delivery", J. Supercritical Fluids, 39 (2006) 102-106.
Ana Rita C. Duarte, M.D. Gordillo, M. Margarida Cardoso, Ana Luísa Simplício and Catarina M.M. Duarte, "Preparation of ethyl cellulose/methyl cellulose blends by supercritical antisolvent precipitation", Int. J. Pharm., 311 (2006) 50.
Ana Rita C. Duarte, Mariana Costa, Ana Luísa Simplício, M. Margarida Cardoso, Catarina M. M. Duarte, “Preparation of controlled release microspheres using supercritical fluid technology for delivery of anti-inflammatory drugs”, Int. J. Pharm., 308 (2006) 168-174.
John F. Gilmer, Ana Luísa Simplício and John M. Clancy, "A new amino-masking group capable of pH-triggered amino–drug release", European Journal of Pharmaceutical Sciences, 24 ( 2005) 315. »
1997-2004
Ana Luísa Simplício, John F. Gilmer, Neil Frankish, Helen Sheridan, John J. Walsh, John M. Clancy, "Ionisation characteristics and elimination rates of some aminoindanones determined by capillary electrophoresis", J. Chromatogr. A, 1045 (2004) 233. »
Ana Luísa Simplício, Luís Vilas Boas, "Validation of a solid-phase microextraction method for the determination of organophosphorus pesticides in fruits and fruit juice", J. Chromatogr. A, 833 (1999) 35. »
Ana Luísa Simplício, Luís Vilas Boas, "A Microextracção em Fase Sólida como técnica de preparação de amostras para cromatografia", Química - Boletim da Sociedade Portuguesa de Química, nº 67, (1997).
