Elin Moe Glycosylases Glycosylases structures https://www.itqb.unl.pt/mxunit/research/structural-genomics-lab-1/moeglycosylases.jpeg/view https://www.itqb.unl.pt/mxunit/@@site-logo/mxunit-background900px.jpg Elin Moe Glycosylases Glycosylases structures Click to view full-size image… Size: 734KB Related content Moe Team || DNA repair Our main research activity is within the field of DNA repair, with a strong focus on Base Excision Repair (BER). In order to provide new information to this field we use an integrated structural biology approach and study BER enzymes from a wide range of organisms including the extremely radiation and desiccation resistant bacterium Deinococcus radiodurans, the fish pathogen Aliivibrio salmonicida, the human pathogen Vibrio cholerae, Atlantic cod (Gadus morhua) and human. The majority of our enzymes originate from D. radiodurans, which tolerates 200 times higher radiation doses than other microorganisms, without losing viability. The mechanism behind the high radiation resistance is not known but is probably a result of the dual resistance (radiation and desiccation) and a combination of a highly efficient DNA repair machinery, a densely packed genome and cell wall and an unusual high intracellular concentration of Manganese. The genome possesses an unusual high number of BER enzymes compared to other microorganisms, which indicates that BER is important for the resistance mechanism of this organism. We also have some research activity related to iron metabolism in bacteria and marine biotechnology. In both cases the focus is on structure determination of enzymes which may explain 1) molecular mechanisms underlying iron sequestering and 2) identification of novel enzymes with commercial potential.
