Mutator protein MutT

The mutator enzyme MutT hydrolyses the 8-oxoG containing deoxyribose or ribonucleoside triphosphates to their corresponding monophosphates and inorganic pyrophosphate (PPi) and thus plays an important role in the cell’s sanitization system to prevent incorporation of 8-oxo-dGTP into DNA. We have determined the crystal structure of MutT from the human pathogen V. cholerae (VcMutT) and used it to rationalise cold adapted features of MutT from the fish pathogen A. salmonicida (AsMutT). The link below directs you to the PDB ID of this structure and the corresponding paper where it is described. 

Mutator protein MutT from V. cholerae (VcMutT)